This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2po6
From Proteopedia
(New page: 200px<br /> <applet load="2po6" size="450" color="white" frame="true" align="right" spinBox="true" caption="2po6, resolution 3.200Å" /> '''Crystal structure ...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:2po6. | + | [[Image:2po6.jpg|left|200px]]<br /><applet load="2po6" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2po6" size=" | + | |
caption="2po6, resolution 3.200Å" /> | caption="2po6, resolution 3.200Å" /> | ||
'''Crystal structure of CD1d-lipid-antigen complexed with Beta-2-Microglobulin, NKT15 Alpha-Chain and NKT15 Beta-Chain'''<br /> | '''Crystal structure of CD1d-lipid-antigen complexed with Beta-2-Microglobulin, NKT15 Alpha-Chain and NKT15 Beta-Chain'''<br /> | ||
| Line 6: | Line 5: | ||
==Overview== | ==Overview== | ||
The CD1 family is a large cluster of non-polymorphic, major, histocompatibility complex (MHC) class-I-like molecules that bind distinct, lipid-based antigens that are recognized by T cells. The most studied, group of T cells that interact with lipid antigens are natural killer T, (NKT) cells, which characteristically express a semi-invariant T-cell, receptor (NKT TCR) that specifically recognizes the CD1 family member, CD1d. NKT-cell-mediated recognition of the CD1d-antigen complex has been, implicated in microbial immunity, tumour immunity, autoimmunity and, allergy. Here we describe the structure of a human NKT TCR in complex with, CD1d bound to the potent NKT-cell agonist alpha-galactosylceramide, the, archetypal CD1d-restricted glycolipid. In contrast to T-cell, receptor-peptide-antigen-MHC complexes, the NKT TCR docked parallel to, and at the extreme end of the CD1d-binding cleft, which enables a, lock-and-key type interaction with the lipid antigen. The structure, provides a basis for the interaction between the highly conserved NKT TCR, alpha-chain and the CD1d-antigen complex that is typified in innate, immunity, and also indicates how variability of the NKT TCR beta-chain can, impact on recognition of other CD1d-antigen complexes. These findings, provide direct insight into how a T-cell receptor recognizes a, lipid-antigen-presenting molecule of the immune system. | The CD1 family is a large cluster of non-polymorphic, major, histocompatibility complex (MHC) class-I-like molecules that bind distinct, lipid-based antigens that are recognized by T cells. The most studied, group of T cells that interact with lipid antigens are natural killer T, (NKT) cells, which characteristically express a semi-invariant T-cell, receptor (NKT TCR) that specifically recognizes the CD1 family member, CD1d. NKT-cell-mediated recognition of the CD1d-antigen complex has been, implicated in microbial immunity, tumour immunity, autoimmunity and, allergy. Here we describe the structure of a human NKT TCR in complex with, CD1d bound to the potent NKT-cell agonist alpha-galactosylceramide, the, archetypal CD1d-restricted glycolipid. In contrast to T-cell, receptor-peptide-antigen-MHC complexes, the NKT TCR docked parallel to, and at the extreme end of the CD1d-binding cleft, which enables a, lock-and-key type interaction with the lipid antigen. The structure, provides a basis for the interaction between the highly conserved NKT TCR, alpha-chain and the CD1d-antigen complex that is typified in innate, immunity, and also indicates how variability of the NKT TCR beta-chain can, impact on recognition of other CD1d-antigen complexes. These findings, provide direct insight into how a T-cell receptor recognizes a, lipid-antigen-presenting molecule of the immune system. | ||
| - | |||
| - | ==Disease== | ||
| - | Known disease associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=109700 109700]] | ||
==About this Structure== | ==About this Structure== | ||
| - | 2PO6 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG and AGH as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 2PO6 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> and <scene name='pdbligand=AGH:'>AGH</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PO6 OCA]. |
==Reference== | ==Reference== | ||
| Line 22: | Line 18: | ||
[[Category: cd1d-lipid antigen nkt15 complex]] | [[Category: cd1d-lipid antigen nkt15 complex]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 14:08:23 2008'' |
Revision as of 12:08, 23 January 2008
|
Crystal structure of CD1d-lipid-antigen complexed with Beta-2-Microglobulin, NKT15 Alpha-Chain and NKT15 Beta-Chain
Overview
The CD1 family is a large cluster of non-polymorphic, major, histocompatibility complex (MHC) class-I-like molecules that bind distinct, lipid-based antigens that are recognized by T cells. The most studied, group of T cells that interact with lipid antigens are natural killer T, (NKT) cells, which characteristically express a semi-invariant T-cell, receptor (NKT TCR) that specifically recognizes the CD1 family member, CD1d. NKT-cell-mediated recognition of the CD1d-antigen complex has been, implicated in microbial immunity, tumour immunity, autoimmunity and, allergy. Here we describe the structure of a human NKT TCR in complex with, CD1d bound to the potent NKT-cell agonist alpha-galactosylceramide, the, archetypal CD1d-restricted glycolipid. In contrast to T-cell, receptor-peptide-antigen-MHC complexes, the NKT TCR docked parallel to, and at the extreme end of the CD1d-binding cleft, which enables a, lock-and-key type interaction with the lipid antigen. The structure, provides a basis for the interaction between the highly conserved NKT TCR, alpha-chain and the CD1d-antigen complex that is typified in innate, immunity, and also indicates how variability of the NKT TCR beta-chain can, impact on recognition of other CD1d-antigen complexes. These findings, provide direct insight into how a T-cell receptor recognizes a, lipid-antigen-presenting molecule of the immune system.
About this Structure
2PO6 is a Protein complex structure of sequences from Homo sapiens with and as ligands. Full crystallographic information is available from OCA.
Reference
CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor., Borg NA, Wun KS, Kjer-Nielsen L, Wilce MC, Pellicci DG, Koh R, Besra GS, Bharadwaj M, Godfrey DI, McCluskey J, Rossjohn J, Nature. 2007 Jun 20;. PMID:17581592
Page seeded by OCA on Wed Jan 23 14:08:23 2008
