Ciprofloxacin

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Ciprofloxacin is a broad-spectrum fluoroquinone antibiotic that is generally effective against both aerobic gram-positive and aerobic gram-negative bacteria. Bacterial organisms that have been shown to be targeted by ciprofloxacin are:
Ciprofloxacin is a broad-spectrum fluoroquinone antibiotic that is generally effective against both aerobic gram-positive and aerobic gram-negative bacteria. Bacterial organisms that have been shown to be targeted by ciprofloxacin are:
-
''Aerobic Gram-Positive Bacteria (With Certain Strain Particularities)'':
+
'''Aerobic Gram-Positive Bacteria (With Certain Strain Particularities)''':
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Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus saprophyticus,
+
''Enterococcus faecalis (many strains are only moderately susceptible), Staphylococcus aureus (methicillin-susceptible strains only), Staphylococcus epidermidis (methicillin-susceptible strains only), Staphylococcus saprophyticus,
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Streptococcus pneumoniae, etc.
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Streptococcus pneumoniae (penicillin-susceptible strains only), Streptococcus pyogenes''.
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''Aerobic Gram-Negative Bacteria (With Certain Strain Particularities)'':
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'''Aerobic Gram-Negative Bacteria''':
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Campylobacter jejuni, Citrobacter freundii, Enterobacter cloacae, Escherichia coli, Haemophilus influenzae, etc.
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''Campylobacter jejuni, Citrobacter diversus, Citrobacter freundii, Enterobacter cloacae, Escherichia coli, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis, Morganella morganii, Neisseria gonorrhoeae, Proteus mirabilis, Proteus vulgaris, Providencia rettgeri, Providencia stuartii, Pseudomonas aeruginosa, Salmonella typhi, Serratia marcescens, Shigella boydii, Shigella dysenteriae, Shigella flexneri, Shigella sonnei''
== Structure ==
== Structure ==

Revision as of 05:43, 6 March 2011

Please do NOT make changes to this Sandbox until after May 10, 2011. Sandbox 100 is reserved until then for use by John Ripollone - Messiah College, Grantham, PA (under the supervision of Dr. Hannah Tims).

Molecular Structure of Ciprofloxacin

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Ciprofloxacin

Page under construction - by: John Ripollone, Department of Biological Sciences (in conjunction with the Department of Chemistry and Biochemistry) - Messiah College, Grantham, PA 17027.

General Information

Ciprofloxacin is a broad-spectrum fluoroquinone antibiotic that is generally effective against both aerobic gram-positive and aerobic gram-negative bacteria. Bacterial organisms that have been shown to be targeted by ciprofloxacin are:

Aerobic Gram-Positive Bacteria (With Certain Strain Particularities):

Enterococcus faecalis (many strains are only moderately susceptible), Staphylococcus aureus (methicillin-susceptible strains only), Staphylococcus epidermidis (methicillin-susceptible strains only), Staphylococcus saprophyticus, Streptococcus pneumoniae (penicillin-susceptible strains only), Streptococcus pyogenes.

Aerobic Gram-Negative Bacteria:

Campylobacter jejuni, Citrobacter diversus, Citrobacter freundii, Enterobacter cloacae, Escherichia coli, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis, Morganella morganii, Neisseria gonorrhoeae, Proteus mirabilis, Proteus vulgaris, Providencia rettgeri, Providencia stuartii, Pseudomonas aeruginosa, Salmonella typhi, Serratia marcescens, Shigella boydii, Shigella dysenteriae, Shigella flexneri, Shigella sonnei

Structure

Ciprofloxacin is a 1-cyclopropyl-6-floro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid with molecular formula: C₁₇H₁₈FN₃O₃.


AcrB Multidrug Efflux Pump with Attached Ciprofloxacin

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Twinned Structure of S. Aureus Gyrase Complex with Attached Ciprofloxacin and DNA

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Proteopedia Page Contributors and Editors (what is this?)

John Ripollone, John E. Ripollone, Alexander Berchansky, David Canner

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