Atropine

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= '''Atropine''' =
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== '''Atropine''' ==
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=== Introduction ===
=== Introduction ===
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Atropine is an alkaloid drug derived from levohyscocyamine, a plant compound found in the family Solanaceae<ref> Atropine. Encyclopedia Brittanica. http://www.britannica.com/EBchecked/topic/42015/atropine</ref>. Although it is poisonous, it is used widely in both human and veterinary medicine.
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(image, atropine)
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Atropine is an alkaloid drug derived from levohyscocyamine, a plant compound found in the family Solanaceae<ref> Atropine. Encyclopedia Brittanica. http://www.britannica.com/EBchecked/topic/42015/atropine</ref>. It is a competitive inhibitor of both acetylcholine and phospholipase 2 and has a variety of effects on both humans and animals. Although it is poisonous, in the correct dosages it has a wide variety of medical uses in both human and veterinary medicine.
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=== Function===
=== Function===
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Atropine has several different medicinal functions. Because it binds to acetylcholine receptors,
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Atropine is part of the tropane group alkaloid family, which includes other substances such as cocaine. Atropine binds to acetylcholine receptors, blocking the action of acetylcholine and therefore suppressing the actions of the parasympathetic nervous system<ref> Atropine. New World Encyclopedia. http://www.newworldencyclopedia.org/entry/Atropine </ref>. In humans, it is metabolized approximately 50%, hydrolyzed to tropine and toropic acid, and the remaining unchanged drug is excreted in the urine<ref> Atropine. New World Encyclopedia. http://www.newworldencyclopedia.org/entry/Atropine </ref>.
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Since atropine affects the parasympathetic nervous system, it has a wide variety of effects. It is largely used as an ophthalmic drug, as it paralyzes the accommodation reflex and dilates the pupil<ref> Atropine. New World Encyclopedia. http://www.newworldencyclopedia.org/entry/Atropine </ref>.
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=== History ===
=== History ===
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Lysozyme and its antibacterial properties were first noticed by Laschtschenko in 1909, and then was officially named lysozyme by Alexander Fleming, the same person credited for the accidental discovery of penicillin. The three dimensional structure of lysozyme was then discovered using x-ray crystallography by David Chilton Phillips. It was only the second protein structure and the first enzyme to ever by solved by x-ray crystallography, with the first being myoglobin. In addition to being the first enzyme structure solved by x-ray crystallography, it was also the first to have its full enzymatic mechanism proposed.
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<applet load='1th6' size='350' frame='true' align='right' caption='' />
<applet load='1th6' size='350' frame='true' align='right' caption='' />
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== References ==
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<references/>
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[[User:Lindsey Hayes|Lindsey Hayes]] 03:53, 8 March 2011 (IST)

Revision as of 01:53, 8 March 2011

Please do NOT make changes to this Sandbox. Sandboxes 30-60 are reserved for use by Biochemistry 410 & 412 at Messiah College taught by Dr. Hannah Tims during Fall 2012 and Spring 2013.



Contents

Atropine

Introduction

(image, atropine)

Atropine is an alkaloid drug derived from levohyscocyamine, a plant compound found in the family Solanaceae[1]. It is a competitive inhibitor of both acetylcholine and phospholipase 2 and has a variety of effects on both humans and animals. Although it is poisonous, in the correct dosages it has a wide variety of medical uses in both human and veterinary medicine.


Function

Atropine is part of the tropane group alkaloid family, which includes other substances such as cocaine. Atropine binds to acetylcholine receptors, blocking the action of acetylcholine and therefore suppressing the actions of the parasympathetic nervous system[2]. In humans, it is metabolized approximately 50%, hydrolyzed to tropine and toropic acid, and the remaining unchanged drug is excreted in the urine[3].

Since atropine affects the parasympathetic nervous system, it has a wide variety of effects. It is largely used as an ophthalmic drug, as it paralyzes the accommodation reflex and dilates the pupil[4].


History

PDB ID 1th6

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References

  1. ↑ Atropine. Encyclopedia Brittanica. http://www.britannica.com/EBchecked/topic/42015/atropine
  2. ↑ Atropine. New World Encyclopedia. http://www.newworldencyclopedia.org/entry/Atropine
  3. ↑ Atropine. New World Encyclopedia. http://www.newworldencyclopedia.org/entry/Atropine
  4. ↑ Atropine. New World Encyclopedia. http://www.newworldencyclopedia.org/entry/Atropine

Lindsey Hayes 03:53, 8 March 2011 (IST)

Proteopedia Page Contributors and Editors (what is this?)

Lindsey Hayes, David Canner, Alexander Berchansky, Michal Harel, OCA

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