2dz7

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(New page: 200px<br /><applet load="2dz7" size="350" color="white" frame="true" align="right" spinBox="true" caption="2dz7, resolution 1.60&Aring;" /> '''DNA Octaplex Formati...)
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Revision as of 12:09, 23 January 2008

Image:2dz7.jpg

2dz7, resolution 1.60Å

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DNA Octaplex Formation with an I-Motif of A-Quartets: The Revised Crystal Structure of d(GCGAAAGC)

Overview

The crystal structure of the tetragonal form of d(gcGAAAgc) has been, revised and reasonably refined including the disordered residues. The two, DNA strands form a base-intercalated duplex, and the four duplexes are, assembled according to the crystallographic 222 symmetry to form an, octaplex. In the central region, the eight strands are associated by, I-motif of double A-quartets. Furthermore, eight hydrated-magnesium, cations link the four duplexes to support the octaplex formation. Based on, these structural features, a proposal that folding of d(GAAA)n, found in, the non-coding region of genomes, into an octaplex can induce slippage, during replication to facilitate length polymorphism is presented.

About this Structure

2DZ7 is a Protein complex structure of sequences from [1] with as ligand. Full crystallographic information is available from OCA.

Reference

DNA octaplex formation with an I-motif of water-mediated A-quartets: reinterpretation of the crystal structure of d(GCGAAAGC)., Sato Y, Mitomi K, Sunami T, Kondo J, Takenaka A, J Biochem (Tokyo). 2006 Dec;140(6):759-62. Epub 2006 Oct 24. PMID:17062599

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