2jfb
From Proteopedia
(New page: 200px<br /> <applet load="2jfb" size="450" color="white" frame="true" align="right" spinBox="true" caption="2jfb, resolution 2.50Å" /> '''3D STRUCTURE OF LUM...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2JFB is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Candida_albicans Candida albicans]] with PO4 and MPD as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.9 2.5.1.9]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2JFB OCA]]. | + | 2JFB is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Candida_albicans Candida albicans]] with PO4 and MPD as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Riboflavin_synthase Riboflavin synthase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.9 2.5.1.9]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2JFB OCA]]. |
==Reference== | ==Reference== | ||
Lumazine synthase from Candida albicans as an anti-fungal target enzyme: structural and biochemical basis for drug design., Morgunova E, Saller S, Haase I, Cushman M, Bacher A, Fischer M, Ladenstein R, J Biol Chem. 2007 Jun 8;282(23):17231-41. Epub 2007 Apr 18. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17446177 17446177] | Lumazine synthase from Candida albicans as an anti-fungal target enzyme: structural and biochemical basis for drug design., Morgunova E, Saller S, Haase I, Cushman M, Bacher A, Fischer M, Ladenstein R, J Biol Chem. 2007 Jun 8;282(23):17231-41. Epub 2007 Apr 18. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17446177 17446177] | ||
[[Category: Candida albicans]] | [[Category: Candida albicans]] | ||
| + | [[Category: Riboflavin synthase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Bacher, A.]] | [[Category: Bacher, A.]] | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:40:46 2007'' |
Revision as of 09:36, 30 October 2007
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3D STRUCTURE OF LUMAZINE SYNTHASE FROM CANDIDA ALBICANS
Overview
Lumazine synthase is an enzyme involved in riboflavin biosynthesis in many, plants and microorganisms, including numerous human pathogens. The fact, that the enzymes of the riboflavin biosynthesis pathway are not present in, the human or animal host makes them potential targets for anti-infective, agents. The crystal structure of lumazine synthase from Candida albicans, was solved by molecular replacement and refined at 2.5-Angstrom, resolution. The results of crystallographic investigations and, sedimentation equilibrium experiments clearly indicated the presence of, pentameric assemblies of the enzyme either in crystals or in solution., Isothermal titration calorimetry measurements of the binding reactions of, four different inhibitors revealed high affinity for all four compounds, with ... [(full description)]
About this Structure
2JFB is a [Single protein] structure of sequence from [Candida albicans] with PO4 and MPD as [ligands]. Active as [Riboflavin synthase], with EC number [2.5.1.9]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Lumazine synthase from Candida albicans as an anti-fungal target enzyme: structural and biochemical basis for drug design., Morgunova E, Saller S, Haase I, Cushman M, Bacher A, Fischer M, Ladenstein R, J Biol Chem. 2007 Jun 8;282(23):17231-41. Epub 2007 Apr 18. PMID:17446177
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