Alendronate
From Proteopedia
| Line 9: | Line 9: | ||
== History of Bisphosphonates == | == History of Bisphosphonates == | ||
| - | + | Bisphosphonates were first synthesized in Germany in 1865, but were not studied biologically until 1968. In the interim time, they were used in the textile and fertilizer industries due to their apparent inhibitory effect on calcium carbonate. However, in 1968, a group in Switzerland discovered bisphosphonates in humans after finding inorganic pyrophosphates which inhibited calcium phosphate precipitate in urine and plasma.<ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC138713/?tool=pmcentrez</ref> | |
== Structure == | == Structure == | ||
Revision as of 05:24, 11 March 2011
| Please do NOT make changes to this Sandbox. Sandboxes 30-60 are reserved for use by Biochemistry 410 & 412 at Messiah College taught by Dr. Hannah Tims during Fall 2012 and Spring 2013. |
Contents |
Alendronate (Fosamax®)
Alendronate is commonly known for its use in treatment and prevention of osteoporosis in postmenopausal women and men, but is also used to treat Paget's disease (disease that results in deformed and enlarged bones).[1] Alendronate belongs to the class of nitrogen-containing bisphosphonates, which are inorganic pyrophosphate analogues.
History of Bisphosphonates
Bisphosphonates were first synthesized in Germany in 1865, but were not studied biologically until 1968. In the interim time, they were used in the textile and fertilizer industries due to their apparent inhibitory effect on calcium carbonate. However, in 1968, a group in Switzerland discovered bisphosphonates in humans after finding inorganic pyrophosphates which inhibited calcium phosphate precipitate in urine and plasma.[2]
Structure
Target Protein
|
Side affects of Drug
References
- ↑ http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000018/
- ↑ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC138713/?tool=pmcentrez
