Sandbox Reserved 339

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==Title==
==Title==
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[[Image:{{Information |Description=Cartoon diagram of human {{w|aldose reductase}} in complex with NADP+, {{w|citrate}}, and IDD594, a small molecule inhibitor.<br>Created using]]
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{{Information |Description=Cartoon diagram of human {{w|aldose reductase}} in complex with NADP+, {{w|citrate}}, and IDD594, a small molecule inhibitor.<br>Created using
==References==
==References==
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Revision as of 06:02, 11 March 2011

This Sandbox is Reserved from January 10, 2010, through April 10, 2011 for use in BCMB 307-Proteins course taught by Andrea Gorrell at the University of Northern British Columbia, Prince George, BC, Canada.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • Click the 3D button (when editing, above the wikitext box) to insert Jmol.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing

Contents

Aldose Reductase (2IKH)

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Drag the structure with the mouse to rotate

Wikipedia

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Policosanol, a well-defined mixture of very long chain primary alcohols that is available as a nutraceutical product, has been reported to lower blood cholesterol levels.[1] In summary, this study provides the platform for further structure-guided design hypotheses of novel drug candidates with higher affinity and selectivity.[2]

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{{Information |Description=Cartoon diagram of human Template:W in complex with NADP+, Template:W, and IDD594, a small molecule inhibitor.
Created using

References

  1. ↑ Banerjee S, Ghoshal S, Porter TD. Activation of AMP-kinase by Policosanol Requires Peroxisomal Metabolism. Lipids. 2011 Feb 27. PMID:21359855 doi:10.1007/s11745-011-3540-6
  2. ↑ Steuber H, Heine A, Klebe G. Structural and thermodynamic study on aldose reductase: nitro-substituted inhibitors with strong enthalpic binding contribution. J Mol Biol. 2007 May 4;368(3):618-38. Epub 2006 Dec 15. PMID:17368668 doi:10.1016/j.jmb.2006.12.004
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