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[http://en.wikipedia.org/wiki/Aldose_reductase Wikipedia]
[http://en.wikipedia.org/wiki/Aldose_reductase Wikipedia]
==Introduction==
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Aldose reductase is an oxidoreductase/dehydrogenase enzyme.<ref name="wikipedia"> Wikipedia. Aldose Reductase. http://en.wikipedia.org/wiki/Aldose_reductase </ref>
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Aldose reductase is an oxidoreductase/dehydrogenase enzyme.<ref name="wikipedia"> Wikipedia. Aldose Reductase. http://en.wikipedia.org/wiki/Aldose_reductase </ref> It reduces aldehydes and carbonyl, including monosaccharides to their corresponding alcohol products using NADPH as a cofactor. <ref name="wikipedia"/> <ref name="Steuber"> PMID 17368668 </ref>
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In summary, this study provides the platform for further structure-guided design hypotheses of novel drug candidates with higher affinity and selectivity.<ref name="Steuber"> PMID 17368668 </ref>
 
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Revision as of 06:30, 11 March 2011

This Sandbox is Reserved from January 10, 2010, through April 10, 2011 for use in BCMB 307-Proteins course taught by Andrea Gorrell at the University of Northern British Columbia, Prince George, BC, Canada.
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Contents

Aldose Reductase (2IKH)

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Wikipedia

Introduction

Aldose reductase is an oxidoreductase/dehydrogenase enzyme.[1] It reduces aldehydes and carbonyl, including monosaccharides to their corresponding alcohol products using NADPH as a cofactor. [1] [2]

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References

  1. ↑ 1.0 1.1 Wikipedia. Aldose Reductase. http://en.wikipedia.org/wiki/Aldose_reductase
  2. ↑ Steuber H, Heine A, Klebe G. Structural and thermodynamic study on aldose reductase: nitro-substituted inhibitors with strong enthalpic binding contribution. J Mol Biol. 2007 May 4;368(3):618-38. Epub 2006 Dec 15. PMID:17368668 doi:10.1016/j.jmb.2006.12.004
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