Sandbox 80
From Proteopedia
(→Saquinavir) |
|||
| Line 9: | Line 9: | ||
==Structure== | ==Structure== | ||
| - | The chemical formula of <scene name='Sandbox_80/Stickwireframe/1'>Saquinavir</scene> is (C39)(H54)(N6)(O8)S and the molecular weight is 766.94 g/mol. | + | The chemical formula of <scene name='Sandbox_80/Stickwireframe/1'>Saquinavir</scene> is (C39)(H54)(N6)(O8)S and the molecular weight is 766.94 g/mol. |
| + | |||
| + | ==Protein and Drug interations== | ||
| + | intermolecular forces | ||
| + | attraction | ||
==References== | ==References== | ||
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000973 | http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000973 | ||
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=60934&loc=ec_rcs#pharmaction | http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=60934&loc=ec_rcs#pharmaction | ||
Revision as of 09:59, 11 March 2011
Template:Tims Sandbox Reservation
Contents |
Saquinavir
This is an antiviral drug used to treat HIV by inhibiting proteases in the virus. This inhibition causes the spread of the virus to decrease significantly. The is an enzyme that the virus uses to produce the proteins necessary to assemble more viruses. The common name for saqinavir is fortovase. It functions as peptide-like analogue that binds to of the protein and causes inhibition by preventing the protease from cleaving polyproteins which in turn causes the virus to create non-infectious virus particles.
| |||||||
| 3oxc, resolution 1.16Å () | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , | ||||||
| Gene: | pol (Human immunodeficiency virus 1) | ||||||
| Activity: | HIV-1 retropepsin, with EC number 3.4.23.16 | ||||||
| Related: | 2ien, 3mws, 3nu3, 3cyx, 3d1x, 3d1y, 2nmy, 2nmz, 2nnk, 2nnp | ||||||
| |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure
The chemical formula of is (C39)(H54)(N6)(O8)S and the molecular weight is 766.94 g/mol.
Protein and Drug interations
intermolecular forces attraction
References
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000973 http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=60934&loc=ec_rcs#pharmaction
