2qag
From Proteopedia
(New page: 200px<br /> <applet load="2qag" size="450" color="white" frame="true" align="right" spinBox="true" caption="2qag, resolution 4.00Å" /> '''Crystal structure o...) |
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| - | [[Image:2qag.gif|left|200px]]<br /> | + | [[Image:2qag.gif|left|200px]]<br /><applet load="2qag" size="350" color="white" frame="true" align="right" spinBox="true" |
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caption="2qag, resolution 4.00Å" /> | caption="2qag, resolution 4.00Å" /> | ||
'''Crystal structure of human septin trimer 2/6/7'''<br /> | '''Crystal structure of human septin trimer 2/6/7'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2QAG is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with GDP and GTP as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 2QAG is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=GDP:'>GDP</scene> and <scene name='pdbligand=GTP:'>GTP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QAG OCA]. |
==Reference== | ==Reference== | ||
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[[Category: structural protein]] | [[Category: structural protein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 14:18:08 2008'' |
Revision as of 12:18, 23 January 2008
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Crystal structure of human septin trimer 2/6/7
Overview
Septins are GTP-binding proteins that assemble into homo- and, hetero-oligomers and filaments. Although they have key roles in various, cellular processes, little is known concerning the structure of septin, subunits or the organization and polarity of septin complexes. Here we, present the structures of the human SEPT2 G domain and the heterotrimeric, human SEPT2-SEPT6-SEPT7 complex. The structures reveal a universal bipolar, polymer building block, composed of an extended G domain, which forms, oligomers and filaments by conserved interactions between adjacent, nucleotide-binding sites and/or the amino- and carboxy-terminal, extensions. Unexpectedly, X-ray crystallography and electron microscopy, showed that the predicted coiled coils are not involved in or required for, complex and/or filament formation. The asymmetrical heterotrimers, associate head-to-head to form a hexameric unit that is nonpolarized along, the filament axis but is rotationally asymmetrical. The architecture of, septin filaments differs fundamentally from that of other cytoskeletal, structures.
About this Structure
2QAG is a Protein complex structure of sequences from Homo sapiens with and as ligands. Full crystallographic information is available from OCA.
Reference
Structural insight into filament formation by mammalian septins., Sirajuddin M, Farkasovsky M, Hauer F, Kuhlmann D, Macara IG, Weyand M, Stark H, Wittinghofer A, Nature. 2007 Jul 18;. PMID:17637674
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