1t1p
From Proteopedia
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[[Image:1t1p.png|left|200px]] | [[Image:1t1p.png|left|200px]] | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | [[1t1p]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T1P OCA]. | |
==Reference== | ==Reference== | ||
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[[Category: Whittaker, J.]] | [[Category: Whittaker, J.]] | ||
[[Category: Xu, B.]] | [[Category: Xu, B.]] | ||
| + | [[Category: Hormone/growth factor complex]] | ||
[[Category: Insulin receptor]] | [[Category: Insulin receptor]] | ||
[[Category: Protein unfolding]] | [[Category: Protein unfolding]] | ||
[[Category: Receptor binding]] | [[Category: Receptor binding]] | ||
[[Category: Thr-b12-dkp-insulin]] | [[Category: Thr-b12-dkp-insulin]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:31:31 2009'' | ||
Revision as of 19:00, 14 March 2011
NMR STRUCTURE OF HUMAN INSULIN MUTANT HIS-B10-ASP, VAL-B12-THR, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES
Template:ABSTRACT PUBMED 15276842
About this Structure
1t1p is a 2 chain structure. Full experimental information is available from OCA.
Reference
- Huang K, Xu B, Hu SQ, Chu YC, Hua QX, Qu Y, Li B, Wang S, Wang RY, Nakagawa SH, Theede AM, Whittaker J, De Meyts P, Katsoyannis PG, Weiss MA. How insulin binds: the B-chain alpha-helix contacts the L1 beta-helix of the insulin receptor. J Mol Biol. 2004 Aug 6;341(2):529-50. PMID:15276842 doi:10.1016/j.jmb.2004.05.023
- Nakagawa SH, Tager HS, Steiner DF. Mutational analysis of invariant valine B12 in insulin: implications for receptor binding. Biochemistry. 2000 Dec 26;39(51):15826-35. PMID:11123908
- Kristensen C, Kjeldsen T, Wiberg FC, Schaffer L, Hach M, Havelund S, Bass J, Steiner DF, Andersen AS. Alanine scanning mutagenesis of insulin. J Biol Chem. 1997 May 16;272(20):12978-83. PMID:9148904
- Hu SQ, Burke GT, Schwartz GP, Ferderigos N, Ross JB, Katsoyannis PG. Steric requirements at position B12 for high biological activity in insulin. Biochemistry. 1993 Mar 16;32(10):2631-5. PMID:8448120
- Schwartz GP, Burke GT, Katsoyannis PG. [12-asparagine-B] human insulin. An analogue with modification in the hydrophobic core of insulin. Int J Pept Protein Res. 1981 Feb;17(2):243-55. PMID:7014485
