1h7x

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Revision as of 19:08, 14 March 2011

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Template:STRUCTURE 1h7x

DIHYDROPYRIMIDINE DEHYDROGENASE (DPD) FROM PIG, TERNARY COMPLEX OF A MUTANT ENZYME (C671A), NADPH AND 5-FLUOROURACIL

Template:ABSTRACT PUBMED 11179210

About this Structure

1h7x is a 4 chain structure with sequence from Sus scrofa. Full crystallographic information is available from OCA.

Reference

• Dobritzsch D, Schneider G, Schnackerz KD, Lindqvist Y. Crystal structure of dihydropyrimidine dehydrogenase, a major determinant of the pharmacokinetics of the anti-cancer drug 5-fluorouracil. EMBO J. 2001 Feb 15;20(4):650-60. PMID:11179210 doi:10.1093/emboj/20.4.650
• Dobritzsch D, Persson K, Schneider G, Lindqvist Y. Crystallization and preliminary X-ray study of pig liver dihydropyrimidine dehydrogenase. Acta Crystallogr D Biol Crystallogr. 2001 Jan;57(Pt 1):153-5. PMID:11134942