3b7r

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==About this Structure==
==About this Structure==
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3B7R is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B7R OCA].
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[[3b7r]] is a 1 chain structure of [[Leukotriene A4 Hydrolase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B7R OCA].
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==See Also==
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*[[Leukotriene A4 Hydrolase]]
==Reference==
==Reference==
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[[Category: Transition state]]
[[Category: Transition state]]
[[Category: Zinc]]
[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 04:43:22 2009''
 

Revision as of 19:09, 14 March 2011

Image:3b7r.png

Template:STRUCTURE 3b7r

Contents

Leukotriene A4 Hydrolase Complexed with Inhibitor RB3040

Template:ABSTRACT PUBMED 18804029

About this Structure

3b7r is a 1 chain structure of Leukotriene A4 Hydrolase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Tholander F, Muroya A, Roques BP, Fournie-Zaluski MC, Thunnissen MM, Haeggstrom JZ. Structure-based dissection of the active site chemistry of leukotriene A4 hydrolase: implications for M1 aminopeptidases and inhibitor design. Chem Biol. 2008 Sep 22;15(9):920-9. PMID:18804029 doi:10.1016/j.chembiol.2008.07.018
  • Tholander F, Haeggstrom JZ. Assay for rapid analysis of the tri-peptidase activity of LTA4 hydrolase. Proteins. 2007 Jun 1;67(4):1113-8. PMID:17357161 doi:10.1002/prot.21329
  • Rudberg PC, Tholander F, Andberg M, Thunnissen MM, Haeggstrom JZ. Leukotriene A4 hydrolase: identification of a common carboxylate recognition site for the epoxide hydrolase and aminopeptidase substrates. J Biol Chem. 2004 Jun 25;279(26):27376-82. Epub 2004 Apr 12. PMID:15078870 doi:10.1074/jbc.M401031200
  • Rudberg PC, Tholander F, Thunnissen MM, Haeggstrom JZ. Leukotriene A4 hydrolase/aminopeptidase. Glutamate 271 is a catalytic residue with specific roles in two distinct enzyme mechanisms. J Biol Chem. 2002 Jan 11;277(2):1398-404. Epub 2001 Oct 23. PMID:11675384 doi:10.1074/jbc.M106577200
  • Rudberg PC, Tholander F, Thunnissen MM, Samuelsson B, Haeggstrom JZ. Leukotriene A4 hydrolase: selective abrogation of leukotriene B4 formation by mutation of aspartic acid 375. Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4215-20. Epub 2002 Mar 26. PMID:11917124 doi:10.1073/pnas.072090099
  • Thunnissen MM, Nordlund P, Haeggstrom JZ. Crystal structure of human leukotriene A(4) hydrolase, a bifunctional enzyme in inflammation. Nat Struct Biol. 2001 Feb;8(2):131-5. PMID:11175901 doi:10.1038/84117

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