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2biq

From Proteopedia

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{{Seed}}
 
[[Image:2biq.png|left|200px]]
[[Image:2biq.png|left|200px]]
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==About this Structure==
==About this Structure==
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2BIQ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BIQ OCA].
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[[2biq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BIQ OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:15703170</ref><references group="xtra"/>
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<ref group="xtra">PMID:15703170</ref><ref group="xtra">PMID:14534297</ref><ref group="xtra">PMID:8023157</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Fersht, A R.]]
[[Category: Fersht, A R.]]
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[[Category: Tumor suppressor]]
[[Category: Tumor suppressor]]
[[Category: Zinc]]
[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 16:03:53 2009''
 

Revision as of 19:12, 14 March 2011

Image:2biq.png

Template:STRUCTURE 2biq

HUMAN P53 CORE DOMAIN MUTANT T123A-M133L-H168R-V203A-N239Y-R249S-N268D

Template:ABSTRACT PUBMED 15703170

About this Structure

2biq is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Joerger AC, Ang HC, Veprintsev DB, Blair CM, Fersht AR. Structures of p53 cancer mutants and mechanism of rescue by second-site suppressor mutations. J Biol Chem. 2005 Apr 22;280(16):16030-7. Epub 2005 Feb 9. PMID:15703170 doi:http://dx.doi.org/10.1074/jbc.M500179200
  • Joerger AC, Allen MD, Fersht AR. Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations. J Biol Chem. 2004 Jan 9;279(2):1291-6. Epub 2003 Oct 8. PMID:14534297 doi:10.1074/jbc.M309732200
  • Cho Y, Gorina S, Jeffrey PD, Pavletich NP. Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. Science. 1994 Jul 15;265(5170):346-55. PMID:8023157

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