2i9s
From Proteopedia
(New page: 200px<br /><applet load="2i9s" size="450" color="white" frame="true" align="right" spinBox="true" caption="2i9s" /> '''The solution structure of the core of mesode...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:2i9s.jpg|left|200px]]<br /><applet load="2i9s" size=" | + | [[Image:2i9s.jpg|left|200px]]<br /><applet load="2i9s" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2i9s" /> | caption="2i9s" /> | ||
'''The solution structure of the core of mesoderm development (MESD).'''<br /> | '''The solution structure of the core of mesoderm development (MESD).'''<br /> | ||
| Line 7: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2I9S is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http:// | + | 2I9S is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I9S OCA]. |
==Reference== | ==Reference== | ||
| Line 21: | Line 21: | ||
[[Category: ferredoxin-like-fold]] | [[Category: ferredoxin-like-fold]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 14:22:52 2008'' |
Revision as of 12:22, 23 January 2008
|
The solution structure of the core of mesoderm development (MESD).
Overview
Mesoderm development (MESD) is a 224 amino acid mouse protein that acts as, a molecular chaperone for receptors of the low-density lipoprotein, receptor (LDLR) family. By recording (15)N-HSQC-NMR spectra of six, different MESD constructs, we could determine a highly structured core, region corresponding to residues 104-177. Here we firstly present the, solution structure of this highly conserved core of MESD. It shows a, four-stranded anti-parallel beta-sheet and two alpha-helices situated on, one side of the sheet. Although described in the literature as, structurally homologues to ferredoxins, the connectivity of secondary, structure elements is different in the MESD fold. A structural comparison, to entries of the PDB reveals a frequent domain with low sequence homology, annotated as HMA and P-II domains in Pfam.
About this Structure
2I9S is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
The solution structure of the core of mesoderm development (MESD), a chaperone for members of the LDLR-family., Kohler C, Andersen OM, Diehl A, Krause G, Schmieder P, Oschkinat H, J Struct Funct Genomics. 2007 Mar 7;. PMID:17342452
Page seeded by OCA on Wed Jan 23 14:22:52 2008
