2h96
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | + | [[2h96]] is a 4 chain structure of [[Mitogen-activated protein kinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H96 OCA]. | |
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| + | ==See Also== | ||
| + | *[[Mitogen-activated protein kinase]] | ||
==Reference== | ==Reference== | ||
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[[Category: Protein kinase jnk1 inhibitor]] | [[Category: Protein kinase jnk1 inhibitor]] | ||
[[Category: Pyridine carboxamide inhibitor]] | [[Category: Pyridine carboxamide inhibitor]] | ||
| - | + | [[Category: Transcription]] | |
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Revision as of 19:26, 14 March 2011
Contents |
Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide C-jun NH2-terminal Kinase Inhibitors
Template:ABSTRACT PUBMED 16854050
About this Structure
2h96 is a 4 chain structure of Mitogen-activated protein kinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Zhao H, Serby MD, Xin Z, Szczepankiewicz BG, Liu M, Kosogof C, Liu B, Nelson LT, Johnson EF, Wang S, Pederson T, Gum RJ, Clampit JE, Haasch DL, Abad-Zapatero C, Fry EH, Rondinone C, Trevillyan JM, Sham HL, Liu G. Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors. J Med Chem. 2006 Jul 27;49(15):4455-8. PMID:16854050 doi:http://dx.doi.org/10.1021/jm060465l
- Szczepankiewicz BG, Kosogof C, Nelson LT, Liu G, Liu B, Zhao H, Serby MD, Xin Z, Liu M, Gum RJ, Haasch DL, Wang S, Clampit JE, Johnson EF, Lubben TH, Stashko MA, Olejniczak ET, Sun C, Dorwin SA, Haskins K, Abad-Zapatero C, Fry EH, Hutchins CW, Sham HL, Rondinone CM, Trevillyan JM. Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. J Med Chem. 2006 Jun 15;49(12):3563-80. PMID:16759099 doi:http://dx.doi.org/10.1021/jm060199b
- Liu M, Xin Z, Clampit JE, Wang S, Gum RJ, Haasch DL, Trevillyan JM, Abad-Zapatero C, Fry EH, Sham HL, Liu G. Synthesis and SAR of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as novel, selective c-Jun N-terminal kinase inhibitors. Bioorg Med Chem Lett. 2006 May 15;16(10):2590-4. Epub 2006 Mar 9. PMID:16527482 doi:http://dx.doi.org/10.1016/j.bmcl.2006.02.046
