1w33
From Proteopedia
(New page: 200px<br /> <applet load="1w33" size="450" color="white" frame="true" align="right" spinBox="true" caption="1w33, resolution 2.7Å" /> '''BBCRASP-1 FROM BORRE...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1W33 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Borrelia_burgdorferi Borrelia burgdorferi]] with GOL as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W33 OCA]]. | + | 1W33 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Borrelia_burgdorferi Borrelia burgdorferi]] with GOL as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W33 OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: tick]] | [[Category: tick]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:42:15 2007'' |
Revision as of 09:37, 30 October 2007
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BBCRASP-1 FROM BORRELIA BURGDORFERI
Overview
Borrelia burgdorferi, a spirochete transmitted to human hosts during, feeding of infected Ixodes ticks, is the causative agent of Lyme disease., Serum-resistant B. burgdorferi strains cause a chronic, multisystemic form, of the disease and bind complement factor H (FH) and FH-like protein 1, (FHL-1) on the spirochete surface. Here we report the atomic structure for, the key FHL-1- and FH-binding protein BbCRASP-1 and reveal a homodimer, that presents a novel target for drug design.
About this Structure
1W33 is a [Single protein] structure of sequence from [Borrelia burgdorferi] with GOL as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
A novel fold for the factor H-binding protein BbCRASP-1 of Borrelia burgdorferi., Cordes FS, Roversi P, Kraiczy P, Simon MM, Brade V, Jahraus O, Wallis R, Skerka C, Zipfel PF, Wallich R, Lea SM, Nat Struct Mol Biol. 2005 Mar;12(3):276-7. Epub 2005 Feb 13. PMID:15711564
Page seeded by OCA on Tue Oct 30 11:42:15 2007
Categories: Borrelia burgdorferi | Single protein | Brade, V. | Cordes, F.S. | Goodstadt, L. | Kirschfink, M. | Kraiczy, P. | Lea, S.M. | Ponting, C. | Roversi, P. | Simon, M.M. | Skerka, C. | Wallich, R. | Zipfel, P. | GOL | Complement regulator acquiring surface protein | Factor h binding | Lyme borreliosis | Membrane protein | Tick
