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2hr6

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[[Image:2hr6.png|left|200px]]
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==About this Structure==
==About this Structure==
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2HR6 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HR6 OCA].
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[[2hr6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HR6 OCA].
==Reference==
==Reference==
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[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Jelly roll]]
[[Category: Jelly roll]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:01:31 2009''
 

Revision as of 21:25, 14 March 2011

Image:2hr6.png

Template:STRUCTURE 2hr6

Crystal structure of dUTPase in complex with substrate analogue dUDP and manganese

Template:ABSTRACT PUBMED 17932923

About this Structure

2hr6 is a 1 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

  • Kovari J, Barabas O, Varga B, Bekesi A, Tolgyesi F, Fidy J, Nagy J, Vertessy BG. Methylene substitution at the alpha-beta bridging position within the phosphate chain of dUDP profoundly perturbs ligand accommodation into the dUTPase active site. Proteins. 2008 Apr;71(1):308-19. PMID:17932923 doi:10.1002/prot.21757
  • Barabas O, Pongracz V, Kovari J, Wilmanns M, Vertessy BG. Structural insights into the catalytic mechanism of phosphate ester hydrolysis by dUTPase. J Biol Chem. 2004 Oct 8;279(41):42907-15. Epub 2004 Jun 17. PMID:15208312 doi:10.1074/jbc.M406135200
  • Gonzalez A, Larsson G, Persson R, Cedergren-Zeppezauer E. Atomic resolution structure of Escherichia coli dUTPase determined ab initio. Acta Crystallogr D Biol Crystallogr. 2001 Jun;57(Pt 6):767-74. Epub 2001, May 25. PMID:11375495

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