2q1l
From Proteopedia
(New page: 200px<br /> <applet load="2q1l" size="450" color="white" frame="true" align="right" spinBox="true" caption="2q1l, resolution 2.050Å" /> '''Design and Synthes...) |
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| - | [[Image:2q1l. | + | [[Image:2q1l.jpg|left|200px]]<br /><applet load="2q1l" size="350" color="white" frame="true" align="right" spinBox="true" |
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caption="2q1l, resolution 2.050Å" /> | caption="2q1l, resolution 2.050Å" /> | ||
'''Design and Synthesis of Pyrrole-based, Hepatoselective HMG-CoA Reductase Inhibitors'''<br /> | '''Design and Synthesis of Pyrrole-based, Hepatoselective HMG-CoA Reductase Inhibitors'''<br /> | ||
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==Overview== | ==Overview== | ||
This manuscript describes the design and synthesis of a series of, pyrrole-based inhibitors of HMG-CoA reductase for the treatment of, hypercholesterolemia. Analogs were optimized using structure-based design, and physical property considerations resulting in the identification of, 44, a hepatoselective HMG-CoA reductase inhibitor with excellent acute and, chronic efficacy in a pre-clinical animal models. | This manuscript describes the design and synthesis of a series of, pyrrole-based inhibitors of HMG-CoA reductase for the treatment of, hypercholesterolemia. Analogs were optimized using structure-based design, and physical property considerations resulting in the identification of, 44, a hepatoselective HMG-CoA reductase inhibitor with excellent acute and, chronic efficacy in a pre-clinical animal models. | ||
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| - | ==Disease== | ||
| - | Known disease associated with this structure: Statins, attenuated cholesterol lowering by OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=142910 142910]] | ||
==About this Structure== | ==About this Structure== | ||
| - | 2Q1L is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with 882 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Hydroxymethylglutaryl-CoA_reductase_(NADPH) Hydroxymethylglutaryl-CoA reductase (NADPH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.34 1.1.1.34] Full crystallographic information is available from [http:// | + | 2Q1L is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=882:'>882</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Hydroxymethylglutaryl-CoA_reductase_(NADPH) Hydroxymethylglutaryl-CoA reductase (NADPH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.34 1.1.1.34] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q1L OCA]. |
==Reference== | ==Reference== | ||
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[[Category: statin]] | [[Category: statin]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 14:32:37 2008'' |
Revision as of 12:32, 23 January 2008
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Design and Synthesis of Pyrrole-based, Hepatoselective HMG-CoA Reductase Inhibitors
Overview
This manuscript describes the design and synthesis of a series of, pyrrole-based inhibitors of HMG-CoA reductase for the treatment of, hypercholesterolemia. Analogs were optimized using structure-based design, and physical property considerations resulting in the identification of, 44, a hepatoselective HMG-CoA reductase inhibitor with excellent acute and, chronic efficacy in a pre-clinical animal models.
About this Structure
2Q1L is a Single protein structure of sequence from Homo sapiens with as ligand. Active as Hydroxymethylglutaryl-CoA reductase (NADPH), with EC number 1.1.1.34 Full crystallographic information is available from OCA.
Reference
Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors., Pfefferkorn JA, Song Y, Sun KL, Miller SR, Trivedi BK, Choi C, Sorenson RJ, Bratton LD, Unangst PC, Larsen SD, Poel TJ, Cheng XM, Lee C, Erasga N, Auerbach B, Askew V, Dillon L, Hanselman JC, Lin Z, Lu G, Robertson A, Olsen K, Mertz T, Sekerke C, Pavlovsky A, Harris MS, Bainbridge G, Caspers N, Chen H, Eberstadt M, Bioorg Med Chem Lett. 2007 Jun 6;. PMID:17574412
Page seeded by OCA on Wed Jan 23 14:32:37 2008
