2bag
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | + | [[2bag]] is a 1 chain structure of [[Acetylcholinesterase]] with sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BAG OCA]. | |
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| + | ==See Also== | ||
| + | *[[Acetylcholinesterase]] | ||
==Reference== | ==Reference== | ||
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[[Category: Neurotransmitter cleavage]] | [[Category: Neurotransmitter cleavage]] | ||
[[Category: Serine hydrolase]] | [[Category: Serine hydrolase]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:35:09 2009'' | ||
Revision as of 22:07, 14 March 2011
Contents |
3D Structure of Torpedo californica acetylcholinesterase complexed with Ganstigmine
Template:ABSTRACT PUBMED 16913695
About this Structure
2bag is a 1 chain structure of Acetylcholinesterase with sequence from Torpedo californica. Full crystallographic information is available from OCA.
See Also
Reference
- Bartolucci C, Siotto M, Ghidini E, Amari G, Bolzoni PT, Racchi M, Villetti G, Delcanale M, Lamba D. Structural determinants of Torpedo californica acetylcholinesterase inhibition by the novel and orally active carbamate based anti-alzheimer drug ganstigmine (CHF-2819). J Med Chem. 2006 Aug 24;49(17):5051-8. PMID:16913695 doi:http://dx.doi.org/10.1021/jm060293s
- Bartolucci C, Perola E, Cellai L, Brufani M, Lamba D. "Back door" opening implied by the crystal structure of a carbamoylated acetylcholinesterase. Biochemistry. 1999 May 4;38(18):5714-9. PMID:10231521 doi:http://dx.doi.org/10.1021/bi982723p
- Bar-On P, Millard CB, Harel M, Dvir H, Enz A, Sussman JL, Silman I. Kinetic and structural studies on the interaction of cholinesterases with the anti-Alzheimer drug rivastigmine. Biochemistry. 2002 Mar 19;41(11):3555-64. PMID:11888271
- Perola E, Cellai L, Lamba D, Filocamo L, Brufani M. Long chain analogs of physostigmine as potential drugs for Alzheimer's disease: new insights into the mechanism of action in the inhibition of acetylcholinesterase. Biochim Biophys Acta. 1997 Nov 14;1343(1):41-50. PMID:9428657
