3lu9
From Proteopedia
(Difference between revisions)
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[[Image:3lu9.png|left|200px]] | [[Image:3lu9.png|left|200px]] | ||
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{{ABSTRACT_PUBMED_20236938}} | {{ABSTRACT_PUBMED_20236938}} | ||
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- | ==Disease== | ||
- | Known disease associated with this structure: Dysprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]], Hyperprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]], Hypoprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]] | ||
==About this Structure== | ==About this Structure== | ||
- | + | [[3lu9]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LU9 OCA]. | |
==Reference== | ==Reference== | ||
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[[Category: Transmembrane]] | [[Category: Transmembrane]] | ||
[[Category: Zymogen]] | [[Category: Zymogen]] | ||
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- | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 26 08:40:54 2010'' |
Revision as of 22:11, 14 March 2011
Crystal structure of human thrombin mutant S195A in complex with the extracellular fragment of human PAR1
Template:ABSTRACT PUBMED 20236938
About this Structure
3lu9 is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Gandhi PS, Chen Z, Di Cera E. Crystal structure of thrombin bound to the uncleaved extracellular fragment of PAR1. J Biol Chem. 2010 May 14;285(20):15393-8. Epub 2010 Mar 17. PMID:20236938 doi:10.1074/jbc.M110.115337
- Pineda AO, Carrell CJ, Bush LA, Prasad S, Caccia S, Chen ZW, Mathews FS, Di Cera E. Molecular dissection of Na+ binding to thrombin. J Biol Chem. 2004 Jul 23;279(30):31842-53. Epub 2004 May 19. PMID:15152000 doi:http://dx.doi.org/10.1074/jbc.M401756200
Categories: Homo sapiens | Thrombin | Cera, E Di. | Chen, Z. | Gandhi, P S. | Acute phase | Blood coagulation | Calcium | Cell membrane | Cleavage on pair of basic residue | Disease mutation | Disulfide bond | G-protein coupled receptor | Gamma-carboxyglutamic acid | Glycoprotein | Hydrolase | Kringle | Membrane | Pharmaceutical | Phosphoprotein | Polymorphism | Protease | Receptor | Secreted | Serine protease | Transducer | Transmembrane | Zymogen