2x0v
From Proteopedia
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[[Image:2x0v.png|left|200px]] | [[Image:2x0v.png|left|200px]] | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | [[2x0v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X0V OCA]. | |
==Reference== | ==Reference== | ||
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[[Category: Transcription regulation]] | [[Category: Transcription regulation]] | ||
[[Category: Tumor suppressor]] | [[Category: Tumor suppressor]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 25 09:33:09 2010'' | ||
Revision as of 22:15, 14 March 2011
STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO 4-(TRIFLUOROMETHYL)BENZENE-1,2-DIAMINE
Template:ABSTRACT PUBMED 20142040
About this Structure
2x0v is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Basse N, Kaar JL, Settanni G, Joerger AC, Rutherford TJ, Fersht AR. Toward the rational design of p53-stabilizing drugs: probing the surface of the oncogenic Y220C mutant. Chem Biol. 2010 Jan 29;17(1):46-56. PMID:20142040 doi:10.1016/j.chembiol.2009.12.011
- Joerger AC, Ang HC, Fersht AR. Structural basis for understanding oncogenic p53 mutations and designing rescue drugs. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15056-61. Epub 2006 Oct 2. PMID:17015838
Categories: Homo sapiens | Basse, N. | Fersht, A R. | Joerger, A C. | Kaar, J L. | Apoptosis | Cancer | Cell cycle | Host-virus interaction | Li-fraumeni drug discovery | Metal binding | Protein stabilization | Surface crevice | Transcription | Transcription factor | Transcription regulation | Tumor suppressor
