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1oe6
From Proteopedia
(New page: 200px<br /> <applet load="1oe6" size="450" color="white" frame="true" align="right" spinBox="true" caption="1oe6, resolution 2.65Å" /> '''XENOPUS SMUG1, AN A...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1OE6 is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]] with HMU, GOL and IPA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OE6 OCA]]. | + | 1OE6 is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]] with HMU, GOL and IPA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OE6 OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: smug1]] | [[Category: smug1]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:43:57 2007'' |
Revision as of 09:39, 30 October 2007
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XENOPUS SMUG1, AN ANTI-MUTATOR URACIL-DNA GLYCOSYLASE
Overview
Cytosine deamination is a major promutagenic process, generating G:U, mismatches that can cause transition mutations if not repaired. Uracil is, also introduced into DNA via nonmutagenic incorporation of dUTP during, replication. In bacteria, uracil is excised by uracil-DNA glycosylases, (UDG) related to E. coli UNG, and UNG homologs are found in mammals and, viruses. Ung knockout mice display no increase in mutation frequency due, to a second UDG activity, SMUG1, which is specialized for antimutational, uracil excision in mammalian cells. Remarkably, SMUG1 also excises the, oxidation-damage product 5-hydroxymethyluracil (HmU), but like UNG is, inactive against thymine (5-methyluracil), a chemical substructure of HmU., We have solved the crystal structure of SMUG1 complexed with DNA and, ... [(full description)]
About this Structure
1OE6 is a [Protein complex] structure of sequences from [Xenopus laevis] with HMU, GOL and IPA as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structure and specificity of the vertebrate anti-mutator uracil-DNA glycosylase SMUG1., Wibley JE, Waters TR, Haushalter K, Verdine GL, Pearl LH, Mol Cell. 2003 Jun;11(6):1647-59. PMID:12820976
Page seeded by OCA on Tue Oct 30 11:43:57 2007
Categories: Protein complex | Xenopus laevis | Pearl, L.H. | Wibley, J.E.A. | GOL | HMU | IPA | Dna glycosylase | Single stranded | Smug1
