2a4r
From Proteopedia
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[[Image:2a4r.png|left|200px]] | [[Image:2a4r.png|left|200px]] | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | [[2a4r]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A4R OCA]. | |
==Reference== | ==Reference== | ||
| - | + | <ref group="xtra">PMID:16112862</ref><ref group="xtra">PMID:8861917</ref><ref group="xtra">PMID:16087332</ref><ref group="xtra">PMID:8861916</ref><ref group="xtra">PMID:9568891</ref><ref group="xtra">PMID:10702283</ref><references group="xtra"/> | |
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[[Category: Hepatitis c virus]] | [[Category: Hepatitis c virus]] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Arasappan, A.]] | [[Category: Arasappan, A.]] | ||
[[Category: Bogen, S.]] | [[Category: Bogen, S.]] | ||
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[[Category: Prongay, A.]] | [[Category: Prongay, A.]] | ||
[[Category: Saksena, A K.]] | [[Category: Saksena, A K.]] | ||
| - | [[Category: | + | [[Category: Viral protein]] |
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Revision as of 22:27, 14 March 2011
HCV NS3 Protease Domain with a Ketoamide Inhibitor Covalently bound.
Template:ABSTRACT PUBMED 16112862
About this Structure
2a4r is a 4 chain structure with sequence from Hepatitis c virus. Full crystallographic information is available from OCA.
Reference
- Bogen S, Saksena AK, Arasappan A, Gu H, Njoroge FG, Girijavallabhan V, Pichardo J, Butkiewicz N, Prongay A, Madison V. Hepatitis C virus NS3-4A serine protease inhibitors: use of a P2-P1 cyclopropyl alanine combination for improved potency. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4515-9. PMID:16112862 doi:10.1016/j.bmcl.2005.07.009
- Kim JL, Morgenstern KA, Lin C, Fox T, Dwyer MD, Landro JA, Chambers SP, Markland W, Lepre CA, O'Malley ET, Harbeson SL, Rice CM, Murcko MA, Caron PR, Thomson JA. Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide. Cell. 1996 Oct 18;87(2):343-55. PMID:8861917
- Arasappan A, Njoroge FG, Chan TY, Bennett F, Bogen SL, Chen K, Gu H, Hong L, Jao E, Liu YT, Lovey RG, Parekh T, Pike RE, Pinto P, Santhanam B, Venkatraman S, Vaccaro H, Wang H, Yang X, Zhu Z, Mckittrick B, Saksena AK, Girijavallabhan V, Pichardo J, Butkiewicz N, Ingram R, Malcolm B, Prongay A, Yao N, Marten B, Madison V, Kemp S, Levy O, Lim-Wilby M, Tamura S, Ganguly AK. Hepatitis C virus NS3-4A serine protease inhibitors: SAR of P'2 moiety with improved potency. Bioorg Med Chem Lett. 2005 Oct 1;15(19):4180-4. PMID:16087332 doi:10.1016/j.bmcl.2005.06.091
- Love RA, Parge HE, Wickersham JA, Hostomsky Z, Habuka N, Moomaw EW, Adachi T, Hostomska Z. The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site. Cell. 1996 Oct 18;87(2):331-42. PMID:8861916
- Yan Y, Li Y, Munshi S, Sardana V, Cole JL, Sardana M, Steinkuehler C, Tomei L, De Francesco R, Kuo LC, Chen Z. Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: a 2.2 A resolution structure in a hexagonal crystal form. Protein Sci. 1998 Apr;7(4):837-47. PMID:9568891
- Di Marco S, Rizzi M, Volpari C, Walsh MA, Narjes F, Colarusso S, De Francesco R, Matassa VG, Sollazzo M. Inhibition of the hepatitis C virus NS3/4A protease. The crystal structures of two protease-inhibitor complexes. J Biol Chem. 2000 Mar 10;275(10):7152-7. PMID:10702283
