1h2g

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Revision as of 22:41, 14 March 2011

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Template:STRUCTURE 1h2g

ALTERED SUBSTRATE SPECIFICITY MUTANT OF PENICILLIN ACYLASE

Template:ABSTRACT PUBMED 12511194

About this Structure

1h2g is a 2 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

• Morillas M, McVey CE, Brannigan JA, Ladurner AG, Forney LJ, Virden R. Mutations of penicillin acylase residue B71 extend substrate specificity by decreasing steric constraints for substrate binding. Biochem J. 2003 Apr 1;371(Pt 1):143-50. PMID:12511194 doi:10.1042/BJ20021383
• McVey CE, Walsh MA, Dodson GG, Wilson KS, Brannigan JA. Crystal structures of penicillin acylase enzyme-substrate complexes: structural insights into the catalytic mechanism. J Mol Biol. 2001 Oct 12;313(1):139-50. PMID:11601852 doi:http://dx.doi.org/10.1006/jmbi.2001.5043