2wcx
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | {{Seed}} | ||
[[Image:2wcx.png|left|200px]] | [[Image:2wcx.png|left|200px]] | ||
| Line 20: | Line 19: | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[2wcx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WCX OCA]. | |
==Reference== | ==Reference== | ||
| Line 46: | Line 45: | ||
[[Category: Transmembrane]] | [[Category: Transmembrane]] | ||
[[Category: Viral protein]] | [[Category: Viral protein]] | ||
| - | |||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 9 08:30:22 2009'' | ||
Revision as of 22:43, 14 March 2011
CRYSTAL STRUCTURE OF HEPATITIS C VIRUS NS5B POLYMERASE IN COMPLEX WITH THIENOPYRROLE-BASED FINGER-LOOP INHIBITORS
Template:ABSTRACT PUBMED 19672916
About this Structure
2wcx is a 1 chain structure with sequence from Hepatitis c virus. Full crystallographic information is available from OCA.
Reference
- Martin Hernando JI, Ontoria JM, Malancona S, Attenni B, Fiore F, Bonelli F, Koch U, Di Marco S, Colarusso S, Ponzi S, Gennari N, Vignetti SE, Rico Ferreira MD, Habermann J, Rowley M, Narjes F. Optimization of Thienopyrrole-Based Finger-Loop Inhibitors of the Hepatitis C Virus NS5B Polymerase. ChemMedChem. 2009 Aug 11. PMID:19672916 doi:10.1002/cmdc.200900184
- Di Marco S, Volpari C, Tomei L, Altamura S, Harper S, Narjes F, Koch U, Rowley M, De Francesco R, Migliaccio G, Carfi A. Interdomain communication in hepatitis C virus polymerase abolished by small molecule inhibitors bound to a novel allosteric site. J Biol Chem. 2005 Aug 19;280(33):29765-70. Epub 2005 Jun 13. PMID:15955819 doi:http://dx.doi.org/10.1074/jbc.M505423200
Categories: Hepatitis c virus | RNA-directed RNA polymerase | Marco, S Di. | Allosteric inhibitor | Atp-binding | Envelope protein | Genotype 1b | Hcv | Helicase | Hydrolase | Membrane | Nni | Non nucleoside inhibitor | Ns5b | Nucleotide-binding | Polymerase | Rna replication | Rna-binding | Rna-dependent rna-polymerase | Transmembrane | Viral protein
