3bef
From Proteopedia
(Difference between revisions)
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[[Image:3bef.png|left|200px]] | [[Image:3bef.png|left|200px]] | ||
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{{ABSTRACT_PUBMED_18250335}} | {{ABSTRACT_PUBMED_18250335}} | ||
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- | ==Disease== | ||
- | Known disease associated with this structure: Dysprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]], Hyperprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]], Hypoprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]] | ||
==About this Structure== | ==About this Structure== | ||
- | + | [[3bef]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BEF OCA]. | |
==Reference== | ==Reference== | ||
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[[Category: Transmembrane]] | [[Category: Transmembrane]] | ||
[[Category: Zymogen]] | [[Category: Zymogen]] | ||
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- | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 06:04:47 2009'' |
Revision as of 22:45, 14 March 2011
Crystal structure of thrombin bound to the extracellular fragment of PAR1
Template:ABSTRACT PUBMED 18250335
About this Structure
3bef is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Gandhi PS, Chen Z, Mathews FS, Di Cera E. Structural identification of the pathway of long-range communication in an allosteric enzyme. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1832-7. Epub 2008 Feb 4. PMID:18250335
- Pineda AO, Carrell CJ, Bush LA, Prasad S, Caccia S, Chen ZW, Mathews FS, Di Cera E. Molecular dissection of Na+ binding to thrombin. J Biol Chem. 2004 Jul 23;279(30):31842-53. Epub 2004 May 19. PMID:15152000 doi:http://dx.doi.org/10.1074/jbc.M401756200
- Pineda AO, Chen ZW, Bah A, Garvey LC, Mathews FS, Di Cera E. Crystal structure of thrombin in a self-inhibited conformation. J Biol Chem. 2006 Oct 27;281(43):32922-8. Epub 2006 Sep 5. PMID:16954215 doi:http://dx.doi.org/10.1074/jbc.M605530200
Categories: Homo sapiens | Thrombin | Bah, A. | Cera, E Di. | Chen, Z. | Gandhi, P S. | Mathews, F S. | Acute phase | Blood coagulation | Calcium | Cleavage on pair of basic residue | Disease mutation | G-protein coupled receptor | Gamma-carboxyglutamic acid | Glycoprotein | Hydrolase | Kringle | Membrane | Phosphoprotein | Polymorphism | Receptor | Secreted | Serine protease | Transducer | Transmembrane | Zymogen