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2jb4

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Revision as of 22:48, 14 March 2011

Image:2jb4.png

Template:STRUCTURE 2jb4

ISOPENICILLIN N SYNTHASE WITH A 2-THIABICYCLOHEPTAN-6-ONE PRODUCT ANALOGUE

Template:ABSTRACT PUBMED 17907118

About this Structure

2jb4 is a 1 chain structure with sequence from Emericella nidulans. Full crystallographic information is available from OCA.

Reference

  • Stewart AC, Clifton IJ, Adlington RM, Baldwin JE, Rutledge PJ. A cyclobutanone analogue mimics penicillin in binding to isopenicillin N synthase. Chembiochem. 2007 Nov 5;8(16):2003-7. PMID:17907118 doi:10.1002/cbic.200700176
  • Burzlaff NI, Rutledge PJ, Clifton IJ, Hensgens CM, Pickford M, Adlington RM, Roach PL, Baldwin JE. The reaction cycle of isopenicillin N synthase observed by X-ray diffraction. Nature. 1999 Oct 14;401(6754):721-4. PMID:10537113 doi:10.1038/44400

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OCA

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