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1oe8
From Proteopedia
(New page: 200px<br /> <applet load="1oe8" size="450" color="white" frame="true" align="right" spinBox="true" caption="1oe8, resolution 1.65Å" /> '''28KDA GLUTATHIONE S...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1OE8 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Schistosoma_haematobium Schistosoma haematobium]] with GSH as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OE8 OCA]]. | + | 1OE8 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Schistosoma_haematobium Schistosoma haematobium]] with GSH as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OE8 OCA]]. |
==Reference== | ==Reference== | ||
Crystal structure of the 28 kDa glutathione S-transferase from Schistosoma haematobium., Johnson KA, Angelucci F, Bellelli A, Herve M, Fontaine J, Tsernoglou D, Capron A, Trottein F, Brunori M, Biochemistry. 2003 Sep 2;42(34):10084-94. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12939136 12939136] | Crystal structure of the 28 kDa glutathione S-transferase from Schistosoma haematobium., Johnson KA, Angelucci F, Bellelli A, Herve M, Fontaine J, Tsernoglou D, Capron A, Trottein F, Brunori M, Biochemistry. 2003 Sep 2;42(34):10084-94. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12939136 12939136] | ||
| + | [[Category: Glutathione transferase]] | ||
[[Category: Schistosoma haematobium]] | [[Category: Schistosoma haematobium]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: vaccine candidate]] | [[Category: vaccine candidate]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:44:22 2007'' |
Revision as of 09:39, 30 October 2007
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28KDA GLUTATHIONE S-TRANSFERASE FROM SCHISTOSOMA HAEMATOBIUM (GLUTATHIONE SATURATED)
Overview
Schistomiasis is a debilitating parasitic disease which affects 200, million people, causing life-threatening complications in 10% of the, patients. This paper reports the crystal structure of the Schistosoma, haematobium 28 kDa glutathione S-transferase, a multifunctional enzyme, involved in host-parasite interactions and presently considered as a, promising vaccine candidate against schistosomiasis. The structures of the, GSH-free enzyme, as well as the partially (approximately 40%) and almost, fully (approximately 80%) GSH-saturated enzyme, exhibit a unique feature, absent in previous GST structures, concerning the crucial and invariant, Tyr10 side chain which occupies two alternative positions. The canonical, conformer, which allows an H-bond to be formed between the side chain, ... [(full description)]
About this Structure
1OE8 is a [Single protein] structure of sequence from [Schistosoma haematobium] with GSH as [ligand]. Active as [Glutathione transferase], with EC number [2.5.1.18]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Crystal structure of the 28 kDa glutathione S-transferase from Schistosoma haematobium., Johnson KA, Angelucci F, Bellelli A, Herve M, Fontaine J, Tsernoglou D, Capron A, Trottein F, Brunori M, Biochemistry. 2003 Sep 2;42(34):10084-94. PMID:12939136
Page seeded by OCA on Tue Oct 30 11:44:22 2007
