1xh4

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Revision as of 23:08, 14 March 2011

Image:1xh4.png

Template:STRUCTURE 1xh4

Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants

Template:ABSTRACT PUBMED 15634010

About this Structure

1xh4 is a 2 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

  • Breitenlechner CB, Friebe WG, Brunet E, Werner G, Graul K, Thomas U, Kunkele KP, Schafer W, Gassel M, Bossemeyer D, Huber R, Engh RA, Masjost B. Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutants. J Med Chem. 2005 Jan 13;48(1):163-70. PMID:15634010 doi:http://dx.doi.org/10.1021/jm049701n
  • Breitenlechner CB, Wegge T, Berillon L, Graul K, Marzenell K, Friebe WG, Thomas U, Schumacher R, Huber R, Engh RA, Masjost B. Structure-based optimization of novel azepane derivatives as PKB inhibitors. J Med Chem. 2004 Mar 11;47(6):1375-90. PMID:14998327 doi:http://dx.doi.org/10.1021/jm0310479

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OCA

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