1a4u
From Proteopedia
(New page: 200px<br /> <applet load="1a4u" size="450" color="white" frame="true" align="right" spinBox="true" caption="1a4u, resolution 1.92Å" /> '''ALCOHOL DEHYDROGENA...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1A4U is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Scaptodrosophila_lebanonensis Scaptodrosophila lebanonensis]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1A4U OCA]]. | + | 1A4U is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Scaptodrosophila_lebanonensis Scaptodrosophila lebanonensis]]. Active as [[http://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1]]. Structure known Active Sites: , ACA, ACB, NAD, NDA and NDB. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1A4U OCA]]. |
==Reference== | ==Reference== | ||
The refined crystal structure of Drosophila lebanonensis alcohol dehydrogenase at 1.9 A resolution., Benach J, Atrian S, Gonzalez-Duarte R, Ladenstein R, J Mol Biol. 1998 Sep 18;282(2):383-99. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9735295 9735295] | The refined crystal structure of Drosophila lebanonensis alcohol dehydrogenase at 1.9 A resolution., Benach J, Atrian S, Gonzalez-Duarte R, Ladenstein R, J Mol Biol. 1998 Sep 18;282(2):383-99. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9735295 9735295] | ||
| + | [[Category: Alcohol dehydrogenase]] | ||
[[Category: Scaptodrosophila lebanonensis]] | [[Category: Scaptodrosophila lebanonensis]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: short-chain dehydrogenases/reductases]] | [[Category: short-chain dehydrogenases/reductases]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:44:42 2007'' |
Revision as of 09:39, 30 October 2007
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ALCOHOL DEHYDROGENASE FROM DROSOPHILA LEBANONENSIS
Overview
Drosophila alcohol dehydrogenase (DADH; EC 1.1.1.1) is a NAD(H)-dependent, oxidoreductase belonging to the short-chain dehydrogenases/reductases, (SDR) family. This homodimeric enzyme catalyzes the dehydrogenation of, alcohols to their respective ketones or aldehydes in the fruit-fly, Drosophila, both for metabolic assimilation and detoxification purposes., The crystal structure of the apo form of DADH, one of the first, biochemically characterized member of the SDR family, was solved at 1.9 A, resolution by Patterson methods. The initial model was improved by, crystallographic refinement accompanied by electron density averaging, R-factor=20.5%, R-free=23.8%.DADH subunits show an alpha/beta single, domain structure with a characteristic NAD(H) binding motif (Rossmann, fold). The peptide ... [(full description)]
About this Structure
1A4U is a [Single protein] structure of sequence from [Scaptodrosophila lebanonensis]. Active as [Alcohol dehydrogenase], with EC number [1.1.1.1]. Structure known Active Sites: , ACA, ACB, NAD, NDA and NDB. Full crystallographic information is available from [OCA].
Reference
The refined crystal structure of Drosophila lebanonensis alcohol dehydrogenase at 1.9 A resolution., Benach J, Atrian S, Gonzalez-Duarte R, Ladenstein R, J Mol Biol. 1998 Sep 18;282(2):383-99. PMID:9735295
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