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2bev

From Proteopedia

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{{Seed}}
 
[[Image:2bev.png|left|200px]]
[[Image:2bev.png|left|200px]]
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==About this Structure==
==About this Structure==
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2BEV is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BEV OCA].
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[[2bev]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BEV OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:16472748</ref><references group="xtra"/>
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<ref group="xtra">PMID:16472748</ref><ref group="xtra">PMID:15166214</ref><ref group="xtra">PMID:12902323</ref><ref group="xtra">PMID:11069910</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Brautigam, C A.]]
[[Category: Brautigam, C A.]]
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[[Category: Tomchick, D R.]]
[[Category: Tomchick, D R.]]
[[Category: Wynn, R M.]]
[[Category: Wynn, R M.]]
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[[Category: Conformational switch,reactivity]]
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[[Category: Acylation]]
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[[Category: Oxidoreductase,ketoacid dehydrogenase,branched-chain,multi-enzyme complex,acylation,oxidative decarboxylation,maple syrup urine disease,thiamine diphosphate,phosphorylation]]
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[[Category: Branched-chain]]
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[[Category: Conformational switch]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:17:13 2009''
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[[Category: Ketoacid dehydrogenase]]
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[[Category: Maple syrup urine disease]]
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[[Category: Multi- enzyme complex]]
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[[Category: Oxidative decarboxylation]]
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[[Category: Oxidoreductase]]
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[[Category: Phosphorylation]]
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[[Category: Reactivity]]
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[[Category: Thiamine diphosphate]]

Revision as of 23:35, 14 March 2011

Image:2bev.png

Template:STRUCTURE 2bev

REACTIVITY MODULATION OF HUMAN BRANCHED-CHAIN ALPHA-KETOACID DEHYDROGENASE BY AN INTERNAL MOLECULAR SWITCH

Template:ABSTRACT PUBMED 16472748

About this Structure

2bev is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Machius M, Wynn RM, Chuang JL, Li J, Kluger R, Yu D, Tomchick DR, Brautigam CA, Chuang DT. A versatile conformational switch regulates reactivity in human branched-chain alpha-ketoacid dehydrogenase. Structure. 2006 Feb;14(2):287-98. PMID:16472748 doi:10.1016/j.str.2005.10.009
  • Li J, Wynn RM, Machius M, Chuang JL, Karthikeyan S, Tomchick DR, Chuang DT. Cross-talk between thiamin diphosphate binding and phosphorylation loop conformation in human branched-chain alpha-keto acid decarboxylase/dehydrogenase. J Biol Chem. 2004 Jul 30;279(31):32968-78. Epub 2004 May 27. PMID:15166214 doi:http://dx.doi.org/10.1074/jbc.M403611200
  • Wynn RM, Machius M, Chuang JL, Li J, Tomchick DR, Chuang DT. Roles of His291-alpha and His146-beta' in the reductive acylation reaction catalyzed by human branched-chain alpha-ketoacid dehydrogenase: refined phosphorylation loop structure in the active site. J Biol Chem. 2003 Oct 31;278(44):43402-10. Epub 2003 Aug 5. PMID:12902323 doi:http://dx.doi.org/10.1074/jbc.M306204200
  • Wynn RM, Ho R, Chuang JL, Chuang DT. Roles of active site and novel K+ ion-binding site residues in human mitochondrial branched-chain alpha-ketoacid decarboxylase/dehydrogenase. J Biol Chem. 2001 Feb 9;276(6):4168-74. Epub 2000 Nov 7. PMID:11069910 doi:10.1074/jbc.M008038200

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