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2eb9

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(New page: 200px<br /><applet load="2eb9" size="450" color="white" frame="true" align="right" spinBox="true" caption="2eb9, resolution 1.80&Aring;" /> '''Crystal Structure of...)
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[[Image:2eb9.jpg|left|200px]]<br /><applet load="2eb9" size="450" color="white" frame="true" align="right" spinBox="true"
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[[Image:2eb9.jpg|left|200px]]<br /><applet load="2eb9" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2eb9, resolution 1.80&Aring;" />
caption="2eb9, resolution 1.80&Aring;" />
'''Crystal Structure of Cu(II)(Sal-Leu)/apo-Myoglobin'''<br />
'''Crystal Structure of Cu(II)(Sal-Leu)/apo-Myoglobin'''<br />
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==About this Structure==
==About this Structure==
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2EB9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Physeter_catodon Physeter catodon] with PO4, CUS and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2EB9 OCA].
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2EB9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Physeter_catodon Physeter catodon] with <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=CUS:'>CUS</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EB9 OCA].
==Reference==
==Reference==
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[[Category: oxygen storage/transport]]
[[Category: oxygen storage/transport]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 10:00:25 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 14:39:13 2008''

Revision as of 12:39, 23 January 2008


2eb9, resolution 1.80Å

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Crystal Structure of Cu(II)(Sal-Leu)/apo-Myoglobin

Overview

apo-Myoglobin (apo-Mb) was reconstituted with three copper complexes:, CuII(Sal-Phe) (1; Sal-Phe = N-salicylidene-l-phenylalanato), CuII(Sal-Leu), (2; Sal-Leu = N-salicylidene-l-leucinato), and CuII(Sal-Ala) (3; Sal-Ala =, N-salicylidene-l-alanato). The crystal structures of 1.apo-Mb (1.65 A, resolution) and 2.apo-Mb (1.8 A resolution) show that the coordination, geometry around the CuII atom in apo-Mb is distorted square-planar with, tridentate Sal-X and a Nepsilon atom of His64 in the apo-Mb cavity and the, plane of these copper complexes is perpendicular to that of heme. These, results suggest that the apo-Mb cavity can hold metal complexes with, various coordination geometries.

About this Structure

2EB9 is a Single protein structure of sequence from Physeter catodon with , and as ligands. Full crystallographic information is available from OCA.

Reference

Design and Structure Analysis of Artificial Metalloproteins: Selective Coordination of His64 to Copper Complexes with Square-Planar Structure in the apo-Myoglobin Scaffold., Abe S, Ueno T, Reddy PA, Okazaki S, Hikage T, Suzuki A, Yamane T, Nakajima H, Watanabe Y, Inorg Chem. 2007 Jun 25;46(13):5137-5139. Epub 2007 May 25. PMID:17523632

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