2i3i
From Proteopedia
(Difference between revisions)
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[[Image:2i3i.png|left|200px]] | [[Image:2i3i.png|left|200px]] | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | [[2i3i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I3I OCA]. | |
==Reference== | ==Reference== | ||
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[[Category: Apoptosis inhibition]] | [[Category: Apoptosis inhibition]] | ||
[[Category: Drug design]] | [[Category: Drug design]] | ||
| + | [[Category: Inhibitor/apoptosis complex]] | ||
[[Category: Peptide complex]] | [[Category: Peptide complex]] | ||
[[Category: Peptidomimetic]] | [[Category: Peptidomimetic]] | ||
[[Category: Small molecule]] | [[Category: Small molecule]] | ||
[[Category: Zinc binding]] | [[Category: Zinc binding]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 03:36:28 2009'' | ||
Revision as of 00:23, 15 March 2011
Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic
Template:ABSTRACT PUBMED 17168540
About this Structure
2i3i is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Zobel K, Wang L, Varfolomeev E, Franklin MC, Elliott LO, Wallweber HJ, Okawa DC, Flygare JA, Vucic D, Fairbrother WJ, Deshayes K. Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs. ACS Chem Biol. 2006 Sep 19;1(8):525-33. PMID:17168540 doi:10.1021/cb600276q
- Vucic D, Franklin MC, Wallweber HJ, Das K, Eckelman BP, Shin H, Elliott LO, Kadkhodayan S, Deshayes K, Salvesen GS, Fairbrother WJ. Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP. Biochem J. 2005 Jan 1;385(Pt 1):11-20. PMID:15485396 doi:10.1042/BJ20041108
- Franklin MC, Kadkhodayan S, Ackerly H, Alexandru D, Distefano MD, Elliott LO, Flygare JA, Mausisa G, Okawa DC, Ong D, Vucic D, Deshayes K, Fairbrother WJ. Structure and function analysis of peptide antagonists of melanoma inhibitor of apoptosis (ML-IAP). Biochemistry. 2003 Jul 15;42(27):8223-31. PMID:12846571 doi:10.1021/bi034227t
