3oya

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Revision as of 00:32, 15 March 2011

Image:3oya.png

Template:STRUCTURE 3oya

Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and raltegravir at 2.65 resolution

Template:ABSTRACT PUBMED 20118915

About this Structure

3oya is a 4 chain structure with sequence from Human spumaretrovirus. This structure supersedes the now removed PDB entry 3l2t. The March 2011 RCSB PDB Molecule of the Month feature on Integrase by David Goodsell is 10.2210/rcsb_pdb/mom_2011_3. Full crystallographic information is available from OCA.

Reference

  • Hare S, Gupta SS, Valkov E, Engelman A, Cherepanov P. Retroviral intasome assembly and inhibition of DNA strand transfer. Nature. 2010 Mar 11;464(7286):232-6. Epub 2010 Jan 31. PMID:20118915 doi:10.1038/nature08784
  • Hare S, Vos AM, Clayton RF, Thuring JW, Cummings MD, Cherepanov P. Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance. Proc Natl Acad Sci U S A. 2010 Oct 28. PMID:21030679 doi:10.1073/pnas.1010246107

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OCA

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