2pgq
From Proteopedia
(Difference between revisions)
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| - | {{Seed}} | ||
[[Image:2pgq.png|left|200px]] | [[Image:2pgq.png|left|200px]] | ||
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{{ABSTRACT_PUBMED_17636263}} | {{ABSTRACT_PUBMED_17636263}} | ||
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| - | ==Disease== | ||
| - | Known disease associated with this structure: Dysprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]], Hyperprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]], Hypoprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]] | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[2pgq]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PGQ OCA]. | |
==Reference== | ==Reference== | ||
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[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Serine protease]] | [[Category: Serine protease]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 15:29:21 2009'' | ||
Revision as of 00:35, 15 March 2011
Human thrombin mutant C191A-C220A in complex with the inhibitor PPACK
Template:ABSTRACT PUBMED 17636263
About this Structure
2pgq is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Bush-Pelc LA, Marino F, Chen Z, Pineda AO, Mathews FS, Di Cera E. Important role of the cys-191 cys-220 disulfide bond in thrombin function and allostery. J Biol Chem. 2007 Sep 14;282(37):27165-70. Epub 2007 Jul 18. PMID:17636263 doi:10.1074/jbc.M703202200
- Pineda AO, Carrell CJ, Bush LA, Prasad S, Caccia S, Chen ZW, Mathews FS, Di Cera E. Molecular dissection of Na+ binding to thrombin. J Biol Chem. 2004 Jul 23;279(30):31842-53. Epub 2004 May 19. PMID:15152000 doi:http://dx.doi.org/10.1074/jbc.M401756200
