1aot
From Proteopedia
(New page: 200px<br /> <applet load="1aot" size="450" color="white" frame="true" align="right" spinBox="true" caption="1aot" /> '''NMR STRUCTURE OF THE FYN SH2 DOMAIN COMPLEX...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1AOT is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Hamster_polyomavirus Hamster polyomavirus]] and [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.112 2.7.1.112]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AOT OCA]]. | + | 1AOT is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Hamster_polyomavirus Hamster polyomavirus]] and [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Active as [[http://en.wikipedia.org/wiki/Transferred_entry:_2.7.10.1_and_2.7.10.2 Transferred entry: 2.7.10.1 and 2.7.10.2]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.112 2.7.1.112]]. Structure known Active Sites: 3IB and PTR. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AOT OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| + | [[Category: Transferred entry: 2.7.10.1 and 2.7.10.2]] | ||
[[Category: Campbell, I.D.]] | [[Category: Campbell, I.D.]] | ||
[[Category: Day, A.J.]] | [[Category: Day, A.J.]] | ||
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[[Category: signal transduction]] | [[Category: signal transduction]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:45:35 2007'' |
Revision as of 09:40, 30 October 2007
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NMR STRUCTURE OF THE FYN SH2 DOMAIN COMPLEXED WITH A PHOSPHOTYROSYL PEPTIDE, MINIMIZED AVERAGE STRUCTURE
Overview
BACKGROUND: SH2 domains are found in a variety of signal transduction, proteins; they bind phosphotyrosine-containing sequences, allowing them to, both recognize target molecules and regulate intramolecular kinase, activity. Fyn is a member of the Src family of tyrosine kinases that are, involved in signal transduction by association with a number of membrane, receptors. The kinase activity of these signalling proteins is modulated, by switching the binding mode of their SH2 and SH3 domains from, intramolecular to intermolecular. The molecular basis of the signalling, roles observed for different Src family members is still not well, understood; although structures have been determined for the SH2 domains, of other Src family molecules, this is the first structure of the Fyn SH2, domain. ... [(full description)]
About this Structure
1AOT is a [Protein complex] structure of sequences from [Hamster polyomavirus] and [Homo sapiens]. Active as [Transferred entry: 2.7.10.1 and 2.7.10.2], with EC number [2.7.1.112]. Structure known Active Sites: 3IB and PTR. Full crystallographic information is available from [OCA].
Reference
The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificity., Mulhern TD, Shaw GL, Morton CJ, Day AJ, Campbell ID, Structure. 1997 Oct 15;5(10):1313-23. PMID:9351806
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