1wut
From Proteopedia
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[[Image:1wut.png|left|200px]] | [[Image:1wut.png|left|200px]] | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | [[1wut]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUT OCA]. | |
==Reference== | ==Reference== | ||
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[[Category: Wendt, K U.]] | [[Category: Wendt, K U.]] | ||
[[Category: Glycogenolysis]] | [[Category: Glycogenolysis]] | ||
| + | [[Category: Transferase]] | ||
[[Category: Type 2 diabetes]] | [[Category: Type 2 diabetes]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 20:40:12 2009'' | ||
Revision as of 00:41, 15 March 2011
Acyl Ureas as Human Liver Glycogen Phosphorylase Inhibitors for the Treatment of Type 2 Diabetes
Template:ABSTRACT PUBMED 15987904
About this Structure
1wut is a 1 chain structure with sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.
Reference
- Oikonomakos NG, Kosmopoulou MN, Chrysina ED, Leonidas DD, Kostas ID, Wendt KU, Klabunde T, Defossa E. Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs. Protein Sci. 2005 Jul;14(7):1760-71. PMID:15987904 doi:14/7/1760
- Oikonomakos NG, Skamnaki VT, Tsitsanou KE, Gavalas NG, Johnson LN. A new allosteric site in glycogen phosphorylase b as a target for drug interactions. Structure. 2000 Jun 15;8(6):575-84. PMID:10873856
- Zographos SE, Oikonomakos NG, Tsitsanou KE, Leonidas DD, Chrysina ED, Skamnaki VT, Bischoff H, Goldmann S, Watson KA, Johnson LN. The structure of glycogen phosphorylase b with an alkyldihydropyridine-dicarboxylic acid compound, a novel and potent inhibitor. Structure. 1997 Nov 15;5(11):1413-25. PMID:9384557
- Rath VL, Ammirati M, Danley DE, Ekstrom JL, Gibbs EM, Hynes TR, Mathiowetz AM, McPherson RK, Olson TV, Treadway JL, Hoover DJ. Human liver glycogen phosphorylase inhibitors bind at a new allosteric site. Chem Biol. 2000 Sep;7(9):677-82. PMID:10980448
- Lu Z, Bohn J, Bergeron R, Deng Q, Ellsworth KP, Geissler WM, Harris G, McCann PE, McKeever B, Myers RW, Saperstein R, Willoughby CA, Yao J, Chapman K. A new class of glycogen phosphorylase inhibitors. Bioorg Med Chem Lett. 2003 Nov 17;13(22):4125-8. PMID:14592521
Categories: Oryctolagus cuniculus | Phosphorylase | Brachvogel, V. | Burger, H J. | Defossa, E. | Herling, A W. | Kadereit, D. | Klabunde, T. | Kosmopoulou, M N. | Oikonomakos, N G. | Roedern, E von. | Sarubbi, E. | Schmoll, D. | Schonafinger, K. | Wendt, K U. | Glycogenolysis | Transferase | Type 2 diabetes
