2uy1
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(New page: 200px<br /><applet load="2uy1" size="350" color="white" frame="true" align="right" spinBox="true" caption="2uy1, resolution 2.00Å" /> '''CRYSTAL STRUCTURE OF...)
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Revision as of 12:41, 23 January 2008
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CRYSTAL STRUCTURE OF CSTF-77
Overview
The cleavage stimulation factor (CstF) is essential for the first step of, poly(A) tail formation at the 3' ends of mRNAs. This heterotrimeric, complex is built around the 77-kDa protein bridging both CstF-64 and, CstF-50 subunits. We have solved the crystal structure of the 77-kDa, protein from Encephalitozoon cuniculi at a resolution of 2 A. The, structure folds around 11 Half-a-TPR repeats defining two domains. The, crystal structure reveals a tight homodimer exposing phylogenetically, conserved areas for interaction with protein partners. Mapping experiments, identify the C-terminal region of Rna14p, the yeast counterpart of, CstF-77, as the docking domain for Rna15p, the yeast CstF-64 homologue.
About this Structure
2UY1 is a Single protein structure of sequence from Encephalitozoon cuniculi. Full crystallographic information is available from OCA.
Reference
The structure of the CstF-77 homodimer provides insights into CstF assembly., Legrand P, Pinaud N, Minvielle-Sebastia L, Fribourg S, Nucleic Acids Res. 2007;35(13):4515-22. Epub 2007 Jun 21. PMID:17584787
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