1aox
From Proteopedia
(New page: 200px<br /> <applet load="1aox" size="450" color="white" frame="true" align="right" spinBox="true" caption="1aox, resolution 2.1Å" /> '''I DOMAIN FROM INTEGR...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1AOX is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with MG as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AOX OCA]]. | + | 1AOX is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with MG as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Sites: MGA and MGB. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AOX OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: integrin]] | [[Category: integrin]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:45:43 2007'' |
Revision as of 09:41, 30 October 2007
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I DOMAIN FROM INTEGRIN ALPHA2-BETA1
Overview
We have determined the high resolution crystal structure of the I domain, from the alpha-subunit of the integrin alpha2beta1, a cell surface, adhesion receptor for collagen and the human pathogen echovirus-1. The, domain, as expected, adopts the dinucleotide-binding fold, and contains a, metal ion-dependent adhesion site motif with bound Mg2+ at the top of the, beta-sheet. Comparison with the crystal structures of the leukocyte, integrin I domains reveals a new helix (the C-helix) protruding from the, metal ion-dependent adhesion site face of the domain which creates a, groove centered on the magnesium ion. Modeling of a collagen triple helix, into the groove suggests that a glutamic acid side chain from collagen can, coordinate the metal ion, and that the C-helix insert is a major, ... [(full description)]
About this Structure
1AOX is a [Single protein] structure of sequence from [Homo sapiens] with MG as [ligand]. Structure known Active Sites: MGA and MGB. Full crystallographic information is available from [OCA].
Reference
Crystal structure of the I domain from integrin alpha2beta1., Emsley J, King SL, Bergelson JM, Liddington RC, J Biol Chem. 1997 Nov 7;272(45):28512-7. PMID:9353312
Page seeded by OCA on Tue Oct 30 11:45:43 2007
