Sandbox Reserved 350
From Proteopedia
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The structure of Human Coagulation Factor V (FV) is sculpted from, originates from, precursors from a polypeptide to a A1-A2-B-A3-C1-C2 layout which results in the activated (FVa) protein. | The structure of Human Coagulation Factor V (FV) is sculpted from, originates from, precursors from a polypeptide to a A1-A2-B-A3-C1-C2 layout which results in the activated (FVa) protein. | ||
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| - | + | FVa consists of a conserved '''β-Barrel framework''' acting as a scaffold for three loops and a '''C2 domain'''. | |
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'''-Heavy A1-A2 Chain''' | '''-Heavy A1-A2 Chain''' | ||
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Revision as of 04:25, 16 March 2011
| This Sandbox is Reserved from January 10, 2010, through April 10, 2011 for use in BCMB 307-Proteins course taught by Andrea Gorrell at the University of Northern British Columbia, Prince George, BC, Canada. |
To get started:
More help: Help:Editing |
Introduction
- Protein: cHuman Coagulation factor V, 1czv [1]
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| 1czv, resolution 2.40Å () | |||||||||
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| Related: | 1czs, 1czt | ||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Contents |
Structure
The structure of Human Coagulation Factor V (FV) is sculpted from, originates from, precursors from a polypeptide to a A1-A2-B-A3-C1-C2 layout which results in the activated (FVa) protein.
FVa consists of a conserved β-Barrel framework acting as a scaffold for three loops and a C2 domain.
-Heavy A1-A2 Chain
-Light A3-C1-C2 Chain
Which once activated, enhances the ability of factor Xa to generate α-thrombin from prothrombin (5-Fold).
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Function
Free
Free
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Interactions
References
- ↑ 10586886
