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The structure of Human Coagulation Factor V (FV) is sculpted from, originates from, precursors from a polypeptide to a A1-A2-B-A3-C1-C2 layout which results in the activated (FVa) protein.
The structure of Human Coagulation Factor V (FV) is sculpted from, originates from, precursors from a polypeptide to a A1-A2-B-A3-C1-C2 layout which results in the activated (FVa) protein.
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Activated FVa
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FVa consists of a conserved '''β-Barrel framework''' acting as a scaffold for three loops and a '''C2 domain'''.
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'''-Heavy A1-A2 Chain'''
'''-Heavy A1-A2 Chain'''
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Revision as of 04:25, 16 March 2011

This Sandbox is Reserved from January 10, 2010, through April 10, 2011 for use in BCMB 307-Proteins course taught by Andrea Gorrell at the University of Northern British Columbia, Prince George, BC, Canada.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • Click the 3D button (when editing, above the wikitext box) to insert Jmol.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing

Introduction

Protein: cHuman Coagulation factor V, 1czv [1]

PDB ID 1czv

Drag the structure with the mouse to rotate
1czv, resolution 2.40Å ()
Related: 1czs, 1czt
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



Contents

Structure

The structure of Human Coagulation Factor V (FV) is sculpted from, originates from, precursors from a polypeptide to a A1-A2-B-A3-C1-C2 layout which results in the activated (FVa) protein.
FVa consists of a conserved β-Barrel framework acting as a scaffold for three loops and a C2 domain.

-Heavy A1-A2 Chain
-Light A3-C1-C2 Chain
Which once activated, enhances the ability of factor Xa to generate α-thrombin from prothrombin (5-Fold).




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Function

Free
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Interactions







References

  1. ↑ 10586886
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