2ox8
From Proteopedia
(New page: 200px<br /> <applet load="2ox8" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ox8, resolution 2.50Å" /> '''Human Scavenger Rec...) |
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| - | [[Image:2ox8. | + | [[Image:2ox8.jpg|left|200px]]<br /><applet load="2ox8" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2ox8" size=" | + | |
caption="2ox8, resolution 2.50Å" /> | caption="2ox8, resolution 2.50Å" /> | ||
'''Human Scavenger Receptor C-type Lectin carbohydrate-recognition domain.'''<br /> | '''Human Scavenger Receptor C-type Lectin carbohydrate-recognition domain.'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2OX8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN, CL and CA as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 2OX8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=CL:'>CL</scene> and <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OX8 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: c-type lectin]] | [[Category: c-type lectin]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 14:43:41 2008'' |
Revision as of 12:43, 23 January 2008
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Human Scavenger Receptor C-type Lectin carbohydrate-recognition domain.
Overview
The scavenger receptor C-type lectin (SRCL) is unique in the family of, class A scavenger receptors, because in addition to binding sites for, oxidized lipoproteins it also contains a C-type carbohydrate-recognition, domain (CRD) that interacts with specific glycans. Both human and mouse, SRCL are highly specific for the Lewis(x) trisaccharide, which is commonly, found on the surfaces of leukocytes and some tumor cells. Structural, analysis of the CRD of mouse SRCL in complex with Lewis(x) and mutagenesis, show the basis for this specificity. The interaction between mouse SRCL, and Lewis(x) is analogous to the way that selectins and DC-SIGN bind to, related fucosylated glycans, but the mechanism of the interaction is, novel, because it is based on a primary galactose-binding site similar to, the binding site in the asialoglycoprotein receptor. Crystals of the human, receptor lacking bound calcium ions reveal an alternative conformation in, which a glycan ligand would be released during receptor-mediated, endocytosis.
About this Structure
2OX8 is a Single protein structure of sequence from Homo sapiens with , and as ligands. Full crystallographic information is available from OCA.
Reference
Scavenger receptor C-type lectin binds to the leukocyte cell surface glycan Lewis(x) by a novel mechanism., Feinberg H, Taylor ME, Weis WI, J Biol Chem. 2007 Jun 8;282(23):17250-8. Epub 2007 Apr 9. PMID:17420244
Page seeded by OCA on Wed Jan 23 14:43:41 2008
Categories: Homo sapiens | Single protein | Drickamer, K. | Feinberg, H. | Taylor, M.E. | Weis, W.I. | CA | CL | ZN | C-type lectin
