2b9r
From Proteopedia
(New page: 200px<br /> <applet load="2b9r" size="450" color="white" frame="true" align="right" spinBox="true" caption="2b9r, resolution 2.90Å" /> '''Crystal Structure o...) |
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caption="2b9r, resolution 2.90Å" /> | caption="2b9r, resolution 2.90Å" /> | ||
'''Crystal Structure of Human Cyclin B1'''<br /> | '''Crystal Structure of Human Cyclin B1'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2B9R is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 2B9R is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B9R OCA]. |
==Reference== | ==Reference== | ||
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[[Category: cyclin]] | [[Category: cyclin]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 14:46:26 2008'' |
Revision as of 12:46, 23 January 2008
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Crystal Structure of Human Cyclin B1
Overview
Cyclin B is the key regulatory protein controlling mitosis in all, eukaryotes, where it binds cyclin-dependent kinase, cdk1, forming a, complex which initiates the mitotic program through phosphorylation of, select proteins. Cyclin B regulates the activation, subcellular, localization, and substrate specificity of cdk1, and destruction of cyclin, B is necessary for mitotic exit. Overexpression of human cyclin B1 has, been found in numerous cancers and has been associated with tumor, aggressiveness. Here we report the crystal structure of human cyclin B1 to, 2.9 A. Comparison of the structure with cyclin A and cyclin E reveals, remarkably similar N-terminal cyclin box motifs but significant, differences among the C-terminal cyclin box lobes. Divergence in sequence, gives rise to unique interaction surfaces at the proposed cyclin B/cdk1, interface as well as the 'RxL' motif substrate binding site on cyclin B., Examination of the structure provides insight into the molecular basis for, differential affinities of protein based cyclin/cdk inhibitors such as, p27, substrate recognition, and cdk interaction.
About this Structure
2B9R is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The crystal structure of human cyclin B., Petri ET, Errico A, Escobedo L, Hunt T, Basavappa R, Cell Cycle. 2007 Jun;6(11):1342-9. Epub 2007 Jun 14. PMID:17495533
Page seeded by OCA on Wed Jan 23 14:46:26 2008
