2jeu
From Proteopedia
(New page: 200px<br /><applet load="2jeu" size="450" color="white" frame="true" align="right" spinBox="true" caption="2jeu, resolution 2.80Å" /> '''TRANSCRIPTION ACTIVA...) |
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| - | [[Image:2jeu.jpg|left|200px]]<br /><applet load="2jeu" size=" | + | [[Image:2jeu.jpg|left|200px]]<br /><applet load="2jeu" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2jeu, resolution 2.80Å" /> | caption="2jeu, resolution 2.80Å" /> | ||
'''TRANSCRIPTION ACTIVATOR STRUCTURE REVEALS REDOX CONTROL OF A REPLICATION INITIATION REACTION'''<br /> | '''TRANSCRIPTION ACTIVATOR STRUCTURE REVEALS REDOX CONTROL OF A REPLICATION INITIATION REACTION'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2JEU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bovine_papillomavirus_type_1 Bovine papillomavirus type 1]. Full crystallographic information is available from [http:// | + | 2JEU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bovine_papillomavirus_type_1 Bovine papillomavirus type 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEU OCA]. |
==Reference== | ==Reference== | ||
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[[Category: viral transcription factor]] | [[Category: viral transcription factor]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 14:47:33 2008'' |
Revision as of 12:47, 23 January 2008
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TRANSCRIPTION ACTIVATOR STRUCTURE REVEALS REDOX CONTROL OF A REPLICATION INITIATION REACTION
Overview
Redox changes are one of the factors that influence cell-cycle progression, and that control the processes of cellular proliferation, differentiation, senescence and apoptosis. Proteins regulated through redox-sensitive, cysteines have been characterized but specific 'sulphydryl switches' in, replication proteins remain to be identified. In bovine papillomavirus, type-1, DNA replication begins when the viral transcription factor E2, recruits the viral initiator protein E1 to the origin of DNA replication, (ori). Here we show that a novel dimerization interface in the E2, transcription activation domain is stabilized by a disulphide bond., Oxidative cross-linking via Cys57 sequesters the interaction surface, between E1 and E2, preventing pre-initiation and replication initiation, complex formation. Our data demonstrate that as well as a mechanism for, regulating DNA binding, redox reactions can control replication by, modulating the tertiary structure of critical protein factors using a, specific redox sensor.
About this Structure
2JEU is a Single protein structure of sequence from Bovine papillomavirus type 1. Full crystallographic information is available from OCA.
Reference
Transcription activator structure reveals redox control of a replication initiation reaction., Sanders CM, Sizov D, Seavers PR, Ortiz-Lombardia M, Antson AA, Nucleic Acids Res. 2007;35(10):3504-15. Epub 2007 May 3. PMID:17478495
Page seeded by OCA on Wed Jan 23 14:47:33 2008
Categories: Bovine papillomavirus type 1 | Single protein | Antson, A.A. | Ortiz-Lombardia, M. | Sanders, C.M. | Seavers, P.R. | Sizov, D. | Activator | Bovine papillomavirus | Dna replication | Dna-binding | E1 | E2 | Early protein | Nuclear protein | Oxidation | Phosphorylation | Redox control | Replication initiation | Repressor | Transcription | Transcription regulation | Viral transcription factor
