Reserved Sandbox 329
From Proteopedia
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== INTRODUCTION == | == INTRODUCTION == | ||
| - | Terminal uridylyl transferases (TUTases) belong to a superfamily of polymerase ß nucleotidyl transferases.<ref>PMID:17785418</ref> TUTases have been isolated from ''Trypanosoma brucei'' and also ''Leishmania ssp'', parasites causing diseases in humans such as African Sleeping Sickness.<ref>PMID:11893335</ref> | + | Terminal uridylyl transferases (TUTases) belong to a superfamily of polymerase ß nucleotidyl transferases.<ref name="1">PMID:17785418</ref> TUTases have been isolated from ''Trypanosoma brucei'' and also ''Leishmania ssp'', parasites causing diseases in humans such as African Sleeping Sickness.<ref>PMID:11893335</ref> Trypanosomal TUTases have RNA substrates that are shown to select for cognate nucleosides and provide a metal ion binding site for Mg<sup>2+</sup> ions. TUTases function in RNA editing; they add UMP to the 3' hydroxyl group.<ref name="1">PMID:17785418</ref> |
Revision as of 17:14, 16 March 2011
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| 2q0d, resolution 2.00Å () | |||||||||
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| Ligands: | , | ||||||||
| Gene: | TUT4 (Trypanosoma brucei) | ||||||||
| Activity: | RNA uridylyltransferase, with EC number 2.7.7.52 | ||||||||
| Related: | 2ikf, 2nom | ||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Uridylyl transferases
INTRODUCTION
Terminal uridylyl transferases (TUTases) belong to a superfamily of polymerase ß nucleotidyl transferases.Cite error: Invalid <ref> tag;
name cannot be a simple integer. Use a descriptive title TUTases have been isolated from Trypanosoma brucei and also Leishmania ssp, parasites causing diseases in humans such as African Sleeping Sickness.[1] Trypanosomal TUTases have RNA substrates that are shown to select for cognate nucleosides and provide a metal ion binding site for Mg2+ ions. TUTases function in RNA editing; they add UMP to the 3' hydroxyl group.Cite error: Invalid <ref> tag;
name cannot be a simple integer. Use a descriptive title
The bound ligand is an with two Mg2+ ions.
