Sandbox7 Eric Martz
From Proteopedia
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<Structure load='2adp' size='450' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /> | <Structure load='2adp' size='450' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /> | ||
| - | One of the more interesting cases, perhaps, is Human Manganese Superoxide Dismutase [[ | + | One of the more interesting cases, perhaps, is Human Manganese Superoxide Dismutase, for which structures are available for the wild type [[2adq]], shown at right (restore initial scene), and the nitrated form, [[2adp]]. |
<scene name='Sandbox7_Eric_Martz/Contacts_to_nitrotyrosine/1'>Contacts to nitrotyrosine</scene> | <scene name='Sandbox7_Eric_Martz/Contacts_to_nitrotyrosine/1'>Contacts to nitrotyrosine</scene> | ||
==See Also== | ==See Also== | ||
* [http://en.wikipedia.org/wiki/Nitrotyrosine Nitrotyrosine] in Wikipedia. | * [http://en.wikipedia.org/wiki/Nitrotyrosine Nitrotyrosine] in Wikipedia. | ||
Revision as of 22:47, 17 March 2011
Proposed Title: Nitrotyrosine.
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This page is reserved for a collaboration between User:Eric Martz and Hermes J Garbán. |
Nitrotyrosine results from the post-translational modification of the standard amino acid tyrosine. Reactive nitrogen compounds produced in inflammation are typically responsible. Nitrosylation of tyrosine tends to inactivate enzymes. In March, 2011, there are 13 entries in the PDB containing coordinates for 3-nitrotyrosine (meta-nitro-tyrosine), with the [ID] NIY. These include five sequence-distinct proteins, represented by ribonucleotide reductase 2xap, laccase 3div, Human Manganese Superoxide Dismutase 2adp, Human Glutathione Reductase 1k4q, and bovine Cu,Zn superoxide dismutase 1sda. Not surprisingly, the NO2 adduct, being very hydrophilic, is often on the surface of the protein.
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One of the more interesting cases, perhaps, is Human Manganese Superoxide Dismutase, for which structures are available for the wild type 2adq, shown at right (restore initial scene), and the nitrated form, 2adp.
See Also
- Nitrotyrosine in Wikipedia.
