Sandbox7 Eric Martz
From Proteopedia
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One of the more interesting cases may be Human <font color="#00c000">'''Manganese'''</font> Superoxide Dismutase, for which structures are available for the wild type [[2adq]], shown at right (<scene name='Sandbox7_Eric_Martz/Cartoon/1'>restore initial scene</scene>), and the nitrated form, [[2adp]]. In this structure, <font color="#00c000">'''Mn<sup>++</sup>'''</font> is <scene name='Sandbox7_Eric_Martz/Cartoon/2'>buried</scene>. | One of the more interesting cases may be Human <font color="#00c000">'''Manganese'''</font> Superoxide Dismutase, for which structures are available for the wild type [[2adq]], shown at right (<scene name='Sandbox7_Eric_Martz/Cartoon/1'>restore initial scene</scene>), and the nitrated form, [[2adp]]. In this structure, <font color="#00c000">'''Mn<sup>++</sup>'''</font> is <scene name='Sandbox7_Eric_Martz/Cartoon/2'>buried</scene>. | ||
| - | <scene name='Sandbox7_Eric_Martz/Contacts_to_nitrotyrosine/1'>Contacts to nitrotyrosine</scene> | + | * <scene name='Sandbox7_Eric_Martz/Mn_contacts/1'>Contacts to Mn</scene> |
| + | * <scene name='Sandbox7_Eric_Martz/Contacts_to_nitrotyrosine/1'>Contacts to nitrotyrosine</scene> | ||
==See Also== | ==See Also== | ||
* [http://en.wikipedia.org/wiki/Nitrotyrosine Nitrotyrosine] in Wikipedia. | * [http://en.wikipedia.org/wiki/Nitrotyrosine Nitrotyrosine] in Wikipedia. | ||
Revision as of 20:36, 18 March 2011
Proposed Title: Nitrotyrosine.
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This page is reserved for a collaboration between User:Eric Martz and Hermes J Garbán. |
Nitrotyrosine results from the post-translational modification of the standard amino acid tyrosine. Reactive nitrogen compounds produced in inflammation are typically responsible. Nitrosylation of tyrosine tends to inactivate enzymes. In March, 2011, there are 13 entries in the PDB containing coordinates for 3-nitrotyrosine (meta-nitro-tyrosine), with the [ID] NIY. These include six sequence-distinct proteins, represented by ribonucleotide reductase 2xof and 2xap, laccase 3div, Human Manganese Superoxide Dismutase 2adp, Human Glutathione Reductase 1k4q, and bovine Cu,Zn superoxide dismutase 1sda. Not surprisingly, the NO2 adduct, being very hydrophilic, is often on the surface of the protein.
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One of the more interesting cases may be Human Manganese Superoxide Dismutase, for which structures are available for the wild type 2adq, shown at right (), and the nitrated form, 2adp. In this structure, Mn++ is .
See Also
- Nitrotyrosine in Wikipedia.
