2p33
From Proteopedia
(New page: 200px<br /> <applet load="2p33" size="450" color="white" frame="true" align="right" spinBox="true" caption="2p33, resolution 2.40Å" /> '''Synthesis and SAR o...) |
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| - | [[Image:2p33. | + | [[Image:2p33.jpg|left|200px]]<br /><applet load="2p33" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2p33" size=" | + | |
caption="2p33, resolution 2.40Å" /> | caption="2p33, resolution 2.40Å" /> | ||
'''Synthesis and SAR of Aminopyrimidines as Novel c-Jun N-Terminal Kinase (JNK) Inhibitors'''<br /> | '''Synthesis and SAR of Aminopyrimidines as Novel c-Jun N-Terminal Kinase (JNK) Inhibitors'''<br /> | ||
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==Overview== | ==Overview== | ||
The development of a series of novel aminopyrimidines as inhibitors of, c-Jun N-terminal kinases is described. The synthesis, in vitro inhibitory, values for JNK1, JNK2 and CDK2, and the in vitro inhibitory value for a, c-Jun cellular assay are discussed. | The development of a series of novel aminopyrimidines as inhibitors of, c-Jun N-terminal kinases is described. The synthesis, in vitro inhibitory, values for JNK1, JNK2 and CDK2, and the in vitro inhibitory value for a, c-Jun cellular assay are discussed. | ||
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| - | ==Disease== | ||
| - | Known diseases associated with this structure: Epileptic encephalopathy, Lennox-Gastaut type OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602897 602897]] | ||
==About this Structure== | ==About this Structure== | ||
| - | 2P33 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with J07 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] Full crystallographic information is available from [http:// | + | 2P33 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=J07:'>J07</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P33 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: jnk3 kinase]] | [[Category: jnk3 kinase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 14:50:15 2008'' |
Revision as of 12:50, 23 January 2008
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Synthesis and SAR of Aminopyrimidines as Novel c-Jun N-Terminal Kinase (JNK) Inhibitors
Overview
The development of a series of novel aminopyrimidines as inhibitors of, c-Jun N-terminal kinases is described. The synthesis, in vitro inhibitory, values for JNK1, JNK2 and CDK2, and the in vitro inhibitory value for a, c-Jun cellular assay are discussed.
About this Structure
2P33 is a Single protein structure of sequence from Homo sapiens with as ligand. Active as Mitogen-activated protein kinase, with EC number 2.7.11.24 Full crystallographic information is available from OCA.
Reference
Synthesis and SAR of aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors., Alam M, Beevers RE, Ceska T, Davenport RJ, Dickson KM, Fortunato M, Gowers L, Haughan AF, James LA, Jones MW, Kinsella N, Lowe C, Meissner JW, Nicolas AL, Perry BG, Phillips DJ, Pitt WR, Platt A, Ratcliffe AJ, Sharpe A, Tait LJ, Bioorg Med Chem Lett. 2007 Jun 15;17(12):3463-7. Epub 2007 Mar 30. PMID:17459703
Page seeded by OCA on Wed Jan 23 14:50:15 2008
