2vx0
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:18434142</ref><ref group="xtra">PMID:18851911</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Receptor protein-tyrosine kinase]] | [[Category: Receptor protein-tyrosine kinase]] | ||
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[[Category: Read, J.]] | [[Category: Read, J.]] | ||
[[Category: Valentine, A L.]] | [[Category: Valentine, A L.]] | ||
| - | [[Category: Atp-binding]] | ||
| - | [[Category: Glycoprotein]] | ||
| - | [[Category: Kinase]] | ||
| - | [[Category: Membrane]] | ||
| - | [[Category: Mutant]] | ||
| - | [[Category: Nucleotide-binding]] | ||
| - | [[Category: Phosphoprotein]] | ||
| - | [[Category: Polymorphism]] | ||
| - | [[Category: Receptor]] | ||
| - | [[Category: Receptor tyrosine kinase]] | ||
| - | [[Category: Transferase]] | ||
| - | [[Category: Transmembrane]] | ||
| - | [[Category: Tyrosine-protein kinase]] | ||
| - | [[Category: Unphosphorylated]] | ||
Revision as of 05:56, 23 March 2011
EPHB4 KINASE DOMAIN INHIBITOR COMPLEX
Template:ABSTRACT PUBMED 18434142
About this Structure
2vx0 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Bardelle C, Cross D, Davenport S, Kettle JG, Ko EJ, Leach AG, Mortlock A, Read J, Roberts NJ, Robins P, Williams EJ. Inhibitors of the tyrosine kinase EphB4. Part 1: Structure-based design and optimization of a series of 2,4-bis-anilinopyrimidines. Bioorg Med Chem Lett. 2008 May 1;18(9):2776-80. Epub 2008 Apr 10. PMID:18434142 doi:10.1016/j.bmcl.2008.04.015
- Bardelle C, Coleman T, Cross D, Davenport S, Kettle JG, Ko EJ, Leach AG, Mortlock A, Read J, Roberts NJ, Robins P, Williams EJ. Inhibitors of the tyrosine kinase EphB4. Part 2: structure-based discovery and optimisation of 3,5-bis substituted anilinopyrimidines. Bioorg Med Chem Lett. 2008 Nov 1;18(21):5717-21. Epub 2008 Sep 27. PMID:18851911 doi:10.1016/j.bmcl.2008.09.087
