1wqz

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(New page: 200px<br /><applet load="1wqz" size="450" color="white" frame="true" align="right" spinBox="true" caption="1wqz, resolution 3.00&Aring;" /> '''Complicated water or...)
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[[Image:1wqz.gif|left|200px]]<br /><applet load="1wqz" size="450" color="white" frame="true" align="right" spinBox="true"
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[[Image:1wqz.gif|left|200px]]<br /><applet load="1wqz" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1wqz, resolution 3.00&Aring;" />
caption="1wqz, resolution 3.00&Aring;" />
'''Complicated water orientations in the minor groove of B-DNA decamer D(CCATTAATGG)2 observed by neutron diffraction measurements'''<br />
'''Complicated water orientations in the minor groove of B-DNA decamer D(CCATTAATGG)2 observed by neutron diffraction measurements'''<br />
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==About this Structure==
==About this Structure==
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1WQZ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with DOD as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1WQZ OCA].
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1WQZ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=DOD:'>DOD</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WQZ OCA].
==Reference==
==Reference==
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[[Category: neutron diffraction]]
[[Category: neutron diffraction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 14:57:05 2008''

Revision as of 12:57, 23 January 2008


1wqz, resolution 3.00Å

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Complicated water orientations in the minor groove of B-DNA decamer D(CCATTAATGG)2 observed by neutron diffraction measurements

Overview

It has long been suspected that the structure and function of a DNA duplex, can be strongly dependent on its degree of hydration. By neutron, diffraction experiments, we have succeeded in determining most of the, hydrogen (H) and deuterium (D) atomic positions in the decameric, d(CCATTAATGG)2 duplex. Moreover, the D positions in 27 D2O molecules have, been determined. In particular, the complex water network in the minor, groove has been observed in detail. By a combined structural analysis, using 2.0 A resolution X-ray and 3.0 A resolution neutron data, it is, clear that the spine of hydration is built up, not only by a simple, hexagonal hydration pattern (as reported in earlier X-ray studies), but, also by many other water bridges hydrogen-bonded to the DNA strands. The, complexity of the hydration pattern in the minor groove is derived from an, extraordinary variety of orientations displayed by the water molecules.

About this Structure

1WQZ is a Protein complex structure of sequences from [1] with as ligand. Full crystallographic information is available from OCA.

Reference

Complicated water orientations in the minor groove of the B-DNA decamer d(CCATTAATGG)2 observed by neutron diffraction measurements., Arai S, Chatake T, Ohhara T, Kurihara K, Tanaka I, Suzuki N, Fujimoto Z, Mizuno H, Niimura N, Nucleic Acids Res. 2005 May 24;33(9):3017-24. Print 2005. PMID:15914673

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